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GRAP2 — IL10

Text-mined interactions from Literome

Song et al., J Surg Res 1999 (Sepsis) : Splenic immune suppression in sepsis : A role for IL-10 induced changes in P38 MAPK signaling
De et al., J Immunol 2000 : Although exogenous hsp27 stimulation activated all three monocyte mitogen activated protein kinase pathways ( extracellular signal related kinase ( ERK ) 1/2, c-Jun N-terminal kinase, and p38 ), only p38 activation was sustained and required for hsp27 induction of monocyte IL-10 , while both ERK 1/2 and p38 activation were required for induction of TNF-alpha when using the p38 inhibitor SB203580 or the ERK inhibitor PD98059
Ling et al., Crit Care Med 2002 : In contrast to its effects on the janus kinase/STAT pathways, interleukin-6 activation of MAP kinases ( extracellular signal regulated kinase-1, extracellular signal regulated kinase-2, and p38 ) was unaffected by endotoxin
Denys et al., J Immunol 2002 : Studies to elucidate the mechanisms underlying the inhibition of TNF-alpha production addressed the effect of IL-10 on the activation of p38 mitogen activated protein kinase and NF-kappaB
Yan et al., J Biol Chem 2002 : This model probiotic also inhibits activation of the pro-apoptotic p38/mitogen activated protein kinase by tumor necrosis factor, interleukin-1alpha , or gamma-interferon
Guo et al., J Biol Chem 2003 (Inflammation) : This strategy established the requirement for p38 activity for the lipopolysaccharide stimulated production of IL-10 , IL-1beta, and IL-6 by the monocytic cell WEHI 274 and the production of IL-6 and TNFalpha stimulated by ligation of the Fc-gamma receptor of the mast cell MC/9
Ohkusu-Tsukada et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : Inhibition of p38 activity in anergic T cells by a chemical inhibitor resulted in the recovery of interleukin 2 (IL-2) and the inhibition of IL-10 secretion
Jung et al., J Clin Immunol 2005 (MAP Kinase Signaling System...) : The analysis of cytokine production using specific inhibitors of the MAPK pathway revealed that both p38 and ERK activation are essential for PPD induced TNF-alpha production, whereas p38 , but not ERK, activation is essential for IL-10 secretion
Sloan et al., J Virol 2007 : Herpes simplex virus remodels T-cell receptor signaling, resulting in p38 dependent selective synthesis of interleukin-10 ... The activation of p38 was required for interleukin-10 synthesis in HSV infected T cells
Lambert et al., J Immunol 2007 : We also demonstrate that the LMP1 dependent p38 and PI3K activation regulates IL-10 induction through discrete mechanisms
Schaljo et al., J Immunol 2009 (Inflammation) : We found that IL-10 initiates a Stat3 dependent increase of TTP expression accompanied by a delayed decrease of p38 MAPK activity
O'Leary et al., Am J Respir Cell Mol Biol 2011 (Granuloma...) : Our results suggest that IL-10 exerts its effects on this early macrophage response in a partly signal transducer and activator of transcription 3 ( STAT3 ) -dependent manner, and independent of mitogen activated protein kinase p38 ( MAPKp38 ) and extracellular regulated kinase 1/2 ( ERK1/2 ) activity
Rasheed et al., Arthritis Res Ther 2010 (Osteoarthritis) : Pomegranate extract inhibits the interleukin-1ß induced activation of MKK-3, p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Patel et al., J Cell Mol Med 2012 (Carcinoma, Non-Small-Cell Lung...) : IL-10 production in non-small cell lung carcinoma patients is regulated by ERK, P38 and COX-2
Foey et al., J Immunol 1998 : Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha : role of the p38 and p42/44 mitogen activated protein kinases