◀ Back to HSP90AA1
HSP90AA1 — KDR
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
Hsp90 (HSP90AA1)
→
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
(modification, collaborate)
Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
Hsp90 (HSP90AA1)
→
VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3)
→
VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
→
VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
Hsp90 (HSP90AA1)
→
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
Hsp90 (HSP90AA1)
→
VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
ROCK (ROCK1)
→
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
alphav/beta3 Integrin complex (ITGAV-ITGB3)
→
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
→
VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
→
RhoA (RHOA)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
None
→
VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3)
(modification, collaborate)
Le Boeuf et al., J Biol Chem 2004
Evidence: mutant phenotype
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
RHOA/GDP complex (RHOA)
→
VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3)
(modification, collaborate)
Le Boeuf et al., J Biol Chem 2004
Evidence: mutant phenotype
-
NCI Pathway Database Integrins in angiogenesis:
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
→
FAK (PTK2)
(modification, activates)
Le Boeuf et al., Mol Biol Cell 2006, Abedi et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
HSP90AA1
→
KDR
(reaction)
Schaller et al., Biochem J 2001, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
-
Reactome Reaction:
HSP90AA1
→
KDR
(indirect_complex)
Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Duval et al., Mol Biol Cell 2007
:
Herein, we report that
VEGFR-2 activation
induces tyrosine phosphorylation of VEGF receptor 2 (VEGFR-2) associated
Hsp90beta
Genin et al., Poult Sci 2012
(Osteochondrodysplasias...) :
Inhibition of
Hsp90 activity in thiram induced TD
resulted in increased
Flk-1 levels, re-instated normal growth-plate angiogenesis and morphology, and abrogated lameness