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PTGS2 — RAC1

Text-mined interactions from Literome

Slice et al., Biochem Biophys Res Commun 2000 : A CRE/ATF element located at -56 was critical for Ras- and Rac induced transactivation of the COX-2 promoter, but was not required for transactivation by Rho
Hahn et al., Biochem J 2002 : Role of Rac and Cdc42 in lysophosphatidic acid mediated cyclo-oxygenase-2 gene expression ... By exclusion of RhoA and non-specific cytoskeletal effects, the results in the present study indicate an important role for Rac and/or Cdc42 in pertussis toxin-sensitive LPA mediated Cox-2 induction
Schmeck et al., Inflammation 2003 : Therefore, RhoA/Rac1/Cdc42 contribute to NF-kappaB dependent LPS- and TNFalpha induced expression of PGHS-2 in EC but had no effect on the activity of expressed COX-1 and COX-2
Zaric et al., J Biol Chem 2005 : We have previously demonstrated that endothelial cell COX-2 is required for integrin alphaVbeta3 dependent activation of Rac-1 and Cdc-42 and for endothelial cell spreading, migration, and angiogenesis ( Dormond, O., Foletti, A., Paroz, C., and Ruegg, C. ( 2001 ) Nat
Chang et al., J Cell Biochem 2005 : Differential regulation of cyclooxygenase 2 expression by small GTPases Ras, Rac1 , and RhoA ... Individual expression of constitutively active Ras, RhoA, or Rac1 was capable of stimulating COX-2 expression in NIH3T3 cells, but co-expression of constitutively active RhoA with either constitutively active Ras or Rac1 was required for full stimulation of COX-2 expression ... Together, our data suggest that constitutively active oncogenic Ras and Rho coordinately stimulate COX-2 expression whereas transient activation of Ras but not RhoA or Rac1 mediates the induction of COX-2 in response to serum
Wu et al., Mol Med 2007 (Neoplasm Recurrence, Local...) : Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas ... Surprisingly, Rac1 mediated phosphorylation of p38 mitogen activated kinase in papilloma cells but not normal cells, and inhibition of p38 with the specific inhibitor SB202190 suppressed COX-2 expression in papilloma cells but had no effect on low-level COX-2 expression in normal cells
Chen et al., Mol Immunol 2009 : Rac1 regulates peptidoglycan induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway ... PGN induced COX-2 expression was attenuated by a Rac1 dominant negative mutant ( RacN17 ), PI3K inhibitors ( wortmannin and LY 294002 ), and an Akt inhibitor ( 1L-6-hydroxymethyl-chiro-inositol2- [ ( R ) -2-O-methyl-3-O-octadecylcarbonate ] )
Wu et al., Int J Cancer 2010 (Lung Neoplasms...) : Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1 mediated COX-2 expression ... We also showed that EGFR activated Rac1 mediates expression of COX-2 through activation of p38 mitogen activated protein kinase