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GNB2L1 — SRC
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of Androgen receptor activity:
Src (SRC)
→
RACK1 (GNB2L1)
(modification, collaborate)
Kraus et al., Cancer Res 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of Androgen receptor activity:
Src (SRC)
→
T-DHT/AR/RACK1/Src complex (AR-GNB2L1-SRC)
(modification, collaborate)
Kraus et al., Cancer Res 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of Androgen receptor activity:
AR/T-DHT complex (AR)
→
T-DHT/AR/RACK1/Src complex (AR-GNB2L1-SRC)
(modification, collaborate)
Kraus et al., Cancer Res 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of Androgen receptor activity:
RACK1 (GNB2L1)
→
T-DHT/AR/RACK1/Src complex (AR-GNB2L1-SRC)
(modification, collaborate)
Kraus et al., Cancer Res 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of Androgen receptor activity:
AR (AR)
→
AR/RACK1/Src complex (AR-GNB2L1-SRC)
(modification, collaborate)
Guo et al., Cancer Cell 2006*, Kraus et al., Cancer Res 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of Androgen receptor activity:
Src (SRC)
→
RACK1 (GNB2L1)
(modification, collaborate)
Guo et al., Cancer Cell 2006*, Kraus et al., Cancer Res 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of Androgen receptor activity:
Src (SRC)
→
AR/RACK1/Src complex (AR-GNB2L1-SRC)
(modification, collaborate)
Guo et al., Cancer Cell 2006*, Kraus et al., Cancer Res 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of Androgen receptor activity:
RACK1 (GNB2L1)
→
AR/RACK1/Src complex (AR-GNB2L1-SRC)
(modification, collaborate)
Guo et al., Cancer Cell 2006*, Kraus et al., Cancer Res 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of Androgen receptor activity:
T-DHT/AR/TIF2/CARM1 complex (AR-NCOA2-CARM1)
→
T-DHT/AR/RACK1/Src complex (AR-GNB2L1-SRC)
(transcription, activates)
Shang et al., Mol Cell 2002, Fu et al., Mol Cell Biol 2003, Majumder et al., Prostate 2006, Kraus et al., Cancer Res 2006
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Syndecan-2-mediated signaling events:
Syndecan-2/RasGAP/Src complex (SDC2-RASA1-SRC)
→
Syndecan-2/RACK1 complex (SDC2-GNB2L1)
(modification, collaborate)
Huang et al., Biochem Biophys Res Commun 2005
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
SRC
—
GNB2L1
(physical association, affinity chromatography technology)
Chen et al., Mol Biol Cell 2008
-
IRef Biogrid Interaction:
SRC
—
GNB2L1
(direct interaction, two hybrid)
Chang et al., Mol Cell Biol 1998*
-
IRef Biogrid Interaction:
SRC
—
GNB2L1
(direct interaction, pull down)
Chang et al., Mol Cell Biol 1998*
-
IRef Biogrid Interaction:
SRC
—
GNB2L1
(physical association, affinity chromatography technology)
Chang et al., Mol Cell Biol 1998*
-
IRef Hprd Interaction:
SRC
—
GNB2L1
(in vitro)
Chang et al., J Biol Chem 2001*, Chang et al., Mol Cell Biol 1998*
-
IRef Hprd Interaction:
SRC
—
GNB2L1
(two hybrid)
Chang et al., J Biol Chem 2001*, Chang et al., Mol Cell Biol 1998*
-
IRef Hprd Interaction:
SRC
—
GNB2L1
(in vivo)
Chang et al., J Biol Chem 2001*, Chang et al., Mol Cell Biol 1998*
-
IRef Mppi Interaction:
SRC
—
GNB2L1
(coimmunoprecipitation)
Chang et al., Mol Cell Biol 1998*
-
IRef Mppi Interaction:
SRC
—
GNB2L1
(copurification)
Chang et al., Mol Cell Biol 1998*
-
IRef Mppi Interaction:
SRC
—
GNB2L1
(two hybrid)
Chang et al., Mol Cell Biol 1998*
-
IRef Ophid Interaction:
SRC
—
GNB2L1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Chang et al., Oncogene 2002
:
Moreover,
Src activity is
necessary for both the tyrosine phosphorylation of RACK1 and the binding of
RACK1 to Src 's SH2 domain that occur following PKC activation
Severino et al., J Cell Physiol 2004
:
Furthermore, we provide evidence that E1A is able to antagonize the inhibitory
effects of
RACK1 on
Src activity
Mamidipudi et al., FEBS Lett 2004
:
Here, we show that
RACK1 partially
inhibits v-Src kinase activity, and the serum- and anchorage independent growth of v-Src transformed cells, but has no effect on focus formation
Miller et al., Oncogene 2004
:
We found that the association of betaIIPKC and
RACK1 is
necessary for
Src phosphorylation of RACK1 ...
Src activity is
required for tyrosine phosphorylation of
RACK1 , and for RACK1 binding to Src, but not to betaIIPKC ... Endogenous
Src kinase activity, as measured by phosphorylation of Sam68 ( a mitotic-specific Src substrate involved in cell cycle regulation and RNA splicing ) or p190RhoGAP ( a Src substrate and GTPase activating protein involved in actin reorganization ),
increases with disruption of the
Src-RACK1 complex, and decreases with enhanced complex formation ...
RACK1 inhibits
Src mediated p190RhoGAP signaling and actin cytoskeleton rearrangement
Mamidipudi et al., Mol Cell Biol 2004
(Neoplasms) :
RACK1 regulates G1/S progression by suppressing
Src kinase activity
Mamidipudi et al., Biochem Biophys Res Commun 2007
:
Our results provide direct physiologic evidence that
RACK1 regulates growth of NIH3T3 cells by suppressing the activity of
Src and other cell cycle regulators in G1, and delaying entry into S phase
Doan et al., Exp Cell Res 2007
:
RACK1 regulates
Src activity and modulates paxillin dynamics during cell migration
Mamidipudi et al., Oncogene 2009
(Colonic Neoplasms) :
Earlier we showed that
RACK1 regulates growth of human colon cells by suppressing
Src activity at G(1) and mitotic checkpoints
Liu et al., Neurol Res 2011
:
At 7 days of final RACK1 administration, the
effects of
RACK1 on
Src and p-ERK disappeared, and morphine place preference was restored
Swaminathan et al., Oncogene 2012
(Colonic Neoplasms...) :
Previously we showed that
Rack1 regulates the growth of colon cells by suppressing
Src activity at G(1) and mitotic checkpoints, and in the intrinsic apoptotic and Akt cell survival pathways
Chang et al., Mol Cell Biol 1998
:
Purified
GST-RACK1 inhibited the in vitro kinase activity of
Src in a concentration dependent manner ...
GST-RACK1 ( 2 microM )
inhibited the activities of purified
Src and Lck tyrosine kinases by 40 to 50 % but did not inhibit the activities of three serine/threonine kinases that we tested