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PLCG2 — RAC2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Piechulek et al., J Biol Chem 2005
:
PLCgamma(2) , but not PLCgamma(1), was markedly
activated in intact cells by constitutively active Rac1 ( G12V ),
Rac2 ( G12V ), and Rac3 ( G12V ) but not by Cdc42 ( G12V ) and RhoA ( G14V ) ...
Activation of
PLCgamma(2) by
Rac2 ( G12V ) in intact cells coincided with a translocation of PLCgamma(2) from the soluble to the particulate fraction
Walliser et al., J Biol Chem 2008
:
Interestingly, of two closely related PLCgamma isoforms, only
PLCgamma(2) has previously been shown to be
activated by
Rac ... Based on reconstitution experiments with isolated PLCgamma variants and Rac2, we show that an unusual pleckstrin homology (PH) domain, designated as the split PH domain ( spPH ), is both necessary and sufficient to effect
activation of
PLCgamma(2) by
Rac2
Bunney et al., Mol Cell 2009
:
Based on this structure, we illustrate distinct requirements for
PLCgamma(2) activation by
Rac and EGF and generate Rac effector mutants that specifically block activation of PLCgamma(2), but not the related PLCbeta(2) isoform
Everett et al., J Biol Chem 2009
:
Replacement of this residue had no effect on folding of the domain and enhanced
Rac activation of
PLC gamma 2 without increasing Rac binding