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CAV2 — EPHB2
Text-mined interactions from Literome
Labrecque et al., Mol Biol Cell 2003
:
Removal of
caveolin and VEGFR-2 from caveolae by cholesterol depletion resulted in an increase in both basal and VEGF induced phosphorylation of VEGFR-2, but
led to the inhibition of VEGF induced
ERK activation and endothelial cell migration, suggesting that localization of VEGFR-2 to these domains is crucial for VEGF mediated signaling
Kawabe et al., Am J Physiol Heart Circ Physiol 2004
:
Taken together,
caveolin in caveolae may keep ERK inactive, but when caveolin is translocated to noncaveolar sites in response to stretch stress, caveolin mediates stretch
induced ERK activation through an association with beta1-integrins/Fyn/Shc
Volonte et al., FASEB J 2005
:
We also demonstrate that down-regulation of endogenous
caveolin-1 expression
activates ERK and that activation of the p42/44 MAP kinase pathway is necessary to promote muscle regeneration
Kim et al., Biochem Biophys Res Commun 2005
:
Direct interaction between ERK and
caveolin-2 was confirmed by immunoprecipitation and phosphorylated
ERK increased the specific interaction in response to insulin
Oh et al., J Cell Biochem 2006
:
However in contrast to adipocytes, phosphorylation of insulin receptor beta (IRbeta) and
Akt/Erk was not
affected by the respective downregulation of
caveolin-1 or caveolin-3 in the muscle cells
Wang et al., Am J Pathol 2007
:
Therefore, human immunodeficiency virus protease inhibitor ritonavir significantly inhibits cholesterol efflux from macrophages, which may be mediated by mitochondrial dysfunction, oxidative stress,
ERK1/2 activation , and down-regulation of scavenger receptor B1 and
caveolin-1
Head et al., FASEB J 2008
(Brain Ischemia) :
Adenovirally mediated expression of
caveolin-1 in neurons from caveolin-1 ( -/- ) mice
restored NMDA mediated enhancement of P-Src and
P-ERK1/2 , redistributed NMDAR2B to buoyant fractions, and enhanced NMDAR2B localization to membrane rafts ... We conclude that
caveolin-1 , perhaps via its ability to scaffold key signaling components, is
essential for NMDAR localization to neuronal membrane rafts, NMDAR/Src tyrosine kinase
family/ERK signaling, and protection of neurons from ischemic injury and cell death
Albinsson et al., Am J Physiol Cell Physiol 2008
(Hypertrophy...) :
In conclusion,
caveolin 1
contributes to low basal
ERK1/2 and Akt activity and is required for Akt dependent signals in response to shear stress ( flow ) but is not essential for trophic effects of stretch ( pressure ) in the vascular wall
Thomas et al., Breast Cancer Res Treat 2010
(Breast Neoplasms) :
The WT-MCF-7 cells showed abundant expression of caveolin-1 which potentiated oestrogen-receptor ( ERalpha ) signalling and promoted cell growth despite
caveolin-1 mediating
inhibition of
ERK signalling ... Recombinant expression of
caveolin-1 in TAM-R cells did not
affect EGFR/ERK activity, potentially due to mislocalisation of caveolin-1 through hyperactivation of the mTOR pathway or altered caveolin-1 phosphorylation
Singh et al., Atherosclerosis 2011
(Atherosclerosis) :
The
effect of increased
caveolin-1 expression on leptin dependent activation of
ERK1/2 and eNOS was determined by Western blot analysis
Feng et al., J Cell Physiol 2012
:
Downregulation of
caveolin-1 significantly
attenuated the FGF2 induced activation of AKT1 and
ERK1/2 and inhibited FGF2 induced cell proliferation, migration and tube formation in oFPAE cells
Huang et al., FASEB J 2011
:
Exposure to HIV-1 infected monocytes
induced phosphorylation of
ERK1/2 and Akt in hCMEC by 2.5- and 3.6-fold, respectively ; however, these effects were attenuated by overexpression of PPARa or PPAR? and by silencing of
caveolin-1 ( cav-1 )
Watson et al., Steroids 2012
(MAP Kinase Signaling System...) :
Estrogen- and xenoestrogen induced
ERK signaling in pituitary tumor cells
involves estrogen receptor-a interactions with G protein-ai and
caveolin I