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MAP3K7 — RELA

Pathways - manually collected, often from reviews:

• KEGG RIG-I-like receptor signaling pathway: MAP3K7 → NFKB1/RELA (protein-protein, activation)
• WikiPathways RIG-I-like Receptor Signaling: MAP3K7 → Complex of NFKB1-RELA (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: RELA — MAP3K7 (in vitro) Huang et al., Cell Death Differ 2006*

Text-mined interactions from Literome

Ninomiya-Tsuji et al., Nature 1999 : Stimulation of TAK1 causes activation of NF-kappaB , which is blocked by dominant negative mutants of NIK, and an inactive TAK1 mutant prevents activation of NF-kappaB that is mediated by IL-1 but not by NIK
Sakurai et al., J Biol Chem 1999 : Here we investigated the molecular mechanism of TAK1 induced NF-kappaB activation ... Dominant negative mutants of IkappaB kinase (IKK) alpha and IKKbeta inhibited TAK1 induced NF-kappaB activation
Irie et al., FEBS Lett 2000 : A kinase negative mutant of TAK1 inhibited the LPS induced NF-kappaB activation both in a macrophage-like cell line, RAW 264.7, and in human embryonic kidney 293 cells expressing toll-like receptor 2 or 4
Mochida et al., Kokubyo Gakkai Zasshi 2000 (MAP Kinase Signaling System) : Here we report that ASK 1 binds to TAK 1 and dissociates TAK 1 from TNF receptor associated factor 6 ( TRAF 6 ), and inhibits TAK 1- and TRAF 6-, but not NF-kappa B-inducing kinase (NIK) induced NF-kappa B activation
Holtmann et al., J Biol Chem 2001 : Expression of the MAP kinase kinase kinase ( MAPKKK ) TAK1 together with its coactivator TAB1 in HeLa cells activated all three pathways and was sufficient to induce IL-8 formation, NF-kappaB + JNK2 mediated transcription from a minimal IL-8 promoter, and p38 MAPK mediated stabilization of a reporter mRNA containing IL-8 derived regulatory mRNA sequences
Yeung et al., Mol Cell Biol 2001 : Raf kinase inhibitor protein interacts with NF-kappaB inducing kinase and TAK1 and inhibits NF-kappaB activation
Mizukami et al., Mol Cell Biol 2002 (MAP Kinase Signaling System) : Dominant negative forms of TAK1 and TAB2 inhibit NF-kappaB activation induced by overexpression of RANK ... Furthermore, in murine monocyte RAW 264.7 cells, dominant negative forms of TAK1 and TAB2 inhibit NF-kappaB activation induced by RANKL and endogenous TAK1 is activated in response to RANKL stimulation
Lee et al., J Biochem Mol Biol 2002 : TAK1 dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB ... The inhibitory effect of the TAK1 mutant on RANK- and TRAF induced NF-kappaB activation was also observed, but less efficiently
Jiang et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Kinase inactive mutants of TAK1 ( TAK1DN ) and PKR ( PKRDN ) inhibit poly ( dI.dC ) -induced TLR3 mediated NFkappaB activation, suggesting that both of these kinases play important roles in this pathway
Cho et al., Toxicol Lett 2003 : The dominant negative mutant forms of TAK1 and NIK inhibited the silica induced NF-kappaB activation in Rat2 cells
Silverman et al., J Biol Chem 2003 : Immune activation of NF-kappaB and JNK requires Drosophila TAK1
Chen et al., J Biol Chem 2004 (Crohn Disease) : Nod2, acting in a reciprocal manner, inhibited TAK1 induced NF-kappaB activation in RICK-deficient embryonic fibroblasts ... Nod2 appears to interact with TAK1 through its LRR region to exert its inhibitory effect on TAK1 induced NF-kappaB activation ... Further, wild-type LRR more effectively suppressed NF-kappaB activation induced by TAK1 than LRR with a 3020insC mutation
Chen et al., Biochem Biophys Res Commun 2004 : Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1 dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways ... Moreover, P6 induces MUC5AC transcription via TLR2-MyD88-IRAK1-TRAF6-TAK1 dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways
Rannou et al., Joint Bone Spine 2006 (Arthritis, Rheumatoid) : When these cytokines bind to their membrane receptor, they set off signaling cascades, with activation of TGFbeta activating kinase ( TAK-1 ), of NF-kappaB by Ikappa-B kinase, of mitogen activated protein kinases ( MAP kinases ), and finally of activator protein-1 (AP-1)
Morlon et al., Hum Mol Genet 2005 (Ectodermal Dysplasia) : TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd ... Moreover, we show that dominant negative forms of TAB2, TRAF6 and TAK1 blocked the NF-kappaB activation induced by Edaradd
Shim et al., Genes Dev 2005 : However, TAK1 is not required for NF-kappaB activation through the alternative pathway following LT-beta signaling
Wu et al., J Biol Chem 2006 (Cell Transformation, Neoplastic) : Furthermore, we showed that TAK1 is required for NF-kappaB activation by LMP1
Haase et al., J Immunol 2005 (Yersinia Infections) : TAK1 is an important activator of the IkappaB kinase complex in the TLR signaling cascade
Uemura et al., J Biol Chem 2006 : TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB
Neumann et al., Biol Chem 2006 : Furthermore, we show that mitogen activated protein kinase kinase kinases ( MAP3K ), like TPL2 ( tumour progression locus 2 ) and transforming growth factor beta activated kinase 1 ( TAK1 ), have no impact on H. pylori induced activation of NF-kappaB
Huang et al., Cell Death Differ 2006 : Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL ... TAK1-DN , MKK6-DN, and SB203580, but not MKK3-DN, also suppressed RANKL stimulation of NF-kappaB transcription activity in a manner dependent on p65 phosphorylation on Ser-536
Ishizawa et al., Biol Cell 2006 : xFADD and xRIP1 synergistically induced the activation of AP-1 and NF-kappaB , both of which were partially mediated by TRAF2 ( tumour-necrosis-factor-receptor associated factor 2 ) and TAK1 ( transforming-growth-factor-beta activated kinase 1 )
Sethi et al., J Biol Chem 2006 : NF-kappaB reporter activity induced by TNFR1, TNF receptor associated death domain, TRAF2, TAK1 , NF-kappaB inducing kinase, and IKKbeta was inhibited by indirubin but not that induced by p65 transfection
Wan et al., Nat Immunol 2006 : In mature thymocytes, TAK1 was required for interleukin 7-mediated survival and T cell receptor dependent activation of transcription factor NF-kappaB and the kinase Jnk
Kettner-Buhrow et al., Biochem Biophys Res Commun 2006 (MAP Kinase Signaling System) : dsiRNA against TAK1 or TAB1 significantly suppressed their target proteins as well as TAK1 mediated activation of NFkappaB , p38 MAPK, and JNK, and of IL-8 transcription
Huangfu et al., J Biol Chem 2006 : Osmotic stress activates the TAK1-JNK pathway while blocking TAK1 mediated NF-kappaB activation : TAO2 regulates TAK1 pathways ... Furthermore, we found that although TAK1 was highly activated upon osmotic stress, it could not induce degradation of IkappaB or activation of NF-kappaB ... We found that TAO2 ( thousand-and-one amino acid kinase 2 ) associates with TAK1 and can inhibit TAK1 mediated activation of NF-kappaB but not of JNK
Sethi et al., Blood 2007 (Neoplasm Invasiveness...) : Celastrol, a novel triterpene, potentiates TNF induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB regulated gene products and TAK1 mediated NF-kappaB activation ... Recent studies indicate that TNF induced IKK activation requires activation of TAK1, and we indeed found that celastrol inhibited the TAK1 induced NF-kappaB activation
Delaney et al., Cell cycle (Georgetown, Tex.) 2006 : For example, NFkappaB signaling in a particular cell may or may not require TAK1 depending on the nature of the activating signal
Gohda et al., Biochem Biophys Res Commun 2007 : These results strongly suggest that unlike cytokine signaling, Tax induced NFkappaB activation does not involve K63 polyubiquitination mediated MAP3K activation
Pandey et al., J Biol Chem 2007 : As examined by DNA binding, we found that butein suppressed tumor necrosis factor (TNF) induced NF-kappaB activation in a dose- and time dependent manner ; suppressed the NF-kappaB activation induced by various inflammatory agents and carcinogens ; and inhibited the NF-kappaB reporter activity induced by TNFR1, TRADD, TRAF2, NIK, TAK1/TAB1 , and IKK-beta
Suzuki et al., J Biol Chem 2007 (Cell Transformation, Viral...) : Constitutive activation of TAK1 by HTLV-1 tax dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB ... Surprisingly, TAK1 was not involved in the activation of NF-kappaB
Pandey et al., Blood 2007 (Neoplasm Metastasis) : GA suppressed NF-kappaB activation induced by various inflammatory agents and carcinogens and this, accompanied by the inhibition of TAK1/TAB1 mediated IKK activation, inhibited IkappaBalpha phosphorylation and degradation, suppressed p65 phosphorylation and nuclear translocation, and finally abrogated NF-kappaB dependent reporter gene expression
Safina et al., Oncogene 2008 (Lung Neoplasms...) : Dn-TAK1 reduces NF-kappaB transcriptional response and inhibition of NF-kappaB reduces expression of MMP-9 and activity of the MMP-9 promoter reporter
Yang et al., J Biol Chem 2007 (Tuberculosis) : We also demonstrate a requirement for the E2-conjugating enzyme Ubc13, the E3 ubiquitin ligase Traf6, and the ubiquitin activated kinase Tak1 in Nod2 mediated NF-kappaB activation
Madhavan et al., J Immunol 2007 : Biomechanical signals suppress TAK1 activation to inhibit NF-kappaB transcriptional activation in fibrochondrocytes
Huang et al., J Immunol 2007 : Requirement for both JAK mediated PI3K signaling and ACT1/TRAF6/TAK1 dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells
Xiao et al., J Biol Chem 2008 : Pellino 3b negatively regulates interleukin-1 induced TAK1 dependent NF kappaB activation
Tang et al., J Exp Med 2008 (Bone Marrow Diseases...) : Activation of TAK1 by proinflammatory cytokines and T and B cell receptors induces the nuclear localization of nuclear factor kappaB (NF-kappaB) and the activation of c-Jun N-terminal kinase (JNK)/AP1 and P38, which play important roles in mediating inflammation, immune responses, T and B cell activation, and epithelial cell survival
Yu et al., J Biol Chem 2008 : Consistently, TAK1 mutant with alanine substitution of these two residues severely inhibits IL-1 induced NFkappaB and AP-1 activities, whereas TAK1 mutant with replacement of these two sites with acidic residues slightly enhances IL-1 induced NFkappaB and AP-1 activities compared with the TAK1 wild-type ... Consistently, TAK1 mutant with alanine substitution of these two residues severely inhibits IL-1 induced NFkappaB and AP-1 activities, whereas TAK1 mutant with replacement of these two sites with acidic residues slightly enhances IL-1 induced NFkappaB and AP-1 activities compared with the TAK1 wild-type
Zhou et al., World J Gastroenterol 2008 (Adenocarcinoma...) : Viable LBG or LBG- ( s ) pretreatment attenuated the expression of TLR4, inhibited the phosphorylation of TAK1 and p38MAPK, prevented the activation of NF-kappaB , and consequently blocked IL-8 production
Fraczek et al., J Biol Chem 2008 : The kinase activity of IL-1 receptor associated kinase 4 is required for interleukin-1 receptor/toll-like receptor induced TAK1 dependent NFkappaB activation
Minakawa et al., Biol Pharm Bull 2008 : In this study, we examined the effect of ISGylation on tumor necrosis factor receptor associated factor ( TRAF) 6/transforming growth factor beta activated kinase ( TAK)-1 dependent NF-kappaB activation
Wang et al., J Biol Chem 2009 (Carcinoma, Hepatocellular) : Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) -induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB ... In the presence of melittin, TRAIL induced apoptosis is significantly increased in TRAIL-resistant HCC cells, which may be attributed to melittin induced TAK1-JNK/p38 activation and melittin mediated inhibition of IkappaBalpha kinase-NFkappaB
Schuman et al., Blood 2009 : The kinase TAK1 is essential for T-cell receptor ( TCR ) -mediated nuclear factor kappaB (NF-kappaB) activation and T-cell development ... However, the role of TAK1 in B-cell receptor (BCR) mediated NF-kappaB activation and B-cell development is not clear ... Thus, TAK1 is critical for B-cell maturation and BCR induced NF-kappaB activation
Kumar et al., J Immunol 2009 (Inflammation) : In this study, we tested the hypothesis that TAK1 ( TGF-beta activated kinase 1 ) is involved in TWEAK induced activation of NF-kappaB and MAPK and expression of proinflammatory protein
Yamaguchi et al., Cell Biol Int 2009 (MAP Kinase Signaling System) : JNK binding protein 1 regulates NF-kappaB activation through TRAF2 and TAK1 ... We also found that JNKBP1 could enhance the NF-kappaB activation induced by TAK1 and TRAF2, and could promote TRAF2 polyubiquitination
Sun et al., Cell Signal 2009 : Together, our results provide the genetic evidence that MEKK3 but not TAK1 is required for LPA receptor mediated IKK-NF-kappaB activation
Henmi et al., Biochem J 2009 : TAK1 ( transforming-growth-factor-beta activated kinase 1 ) mediates the IL-1 signalling pathway to NF-kappaB, and we observed that the TAK1 induced activation of NF-kappaB was suppressed by PP2Ceta-2 expression
Lee et al., Biochim Biophys Acta 2009 : DSCR1-1S also stimulated IL-1R mediated signaling pathways, TAK1 activation, NF-kappaB transactivation , and IL-8 production, all downstream consequences of IL-1R activation
Lamb et al., EMBO Rep 2009 (Inflammation) : CagA physically associates with TAK1 and enhances its activity and TAK1 induced NF-kappaB activation through the tumour necrosis factor receptor associated factor 6-mediated, Lys 63-linked ubiquitination of TAK1
Yamazaki et al., Science signaling 2009 : Here, we showed that TAK1 mediated activation of NF-kappaB required the transient formation of a signaling complex that included tumor necrosis factor receptor associated factor 6 ( TRAF6 ), MEKK3, and TAK1 ... After TAK1 mediated activation of NF-kappaB , TRAF6 subsequently activated NF-kappaB through MEKK3 independently of TAK1, thereby establishing continuous activation of NF-kappaB, which was required for the production of sufficient cytokines
Cheng et al., J Biomed Mater Res A 2010 (Inflammation...) : The critical role for TAK1 in p38MAPK and NFkappaB activation was as well confirmed by the inhibition of p38MAPK and NFkappaB activity following 5Z-7-oxozeaenol, a selective inhibitor of TAK1
Lluis et al., PloS one 2010 : Overexpression of IKK2-EE, a constitutive activator of NF-kappaB, protected TAK1-/- MEFs against TRAIL killing, suggesting that TAK1 activation of NF-kappaB is critical for the viability of cells treated with TRAIL
Srivastava et al., J Biol Chem 2010 : Although both the TAK1 and the CARMA1 binding sites in ADAP are essential for IkappaB alpha phosphorylation and degradation and NF-kappaB nuclear translocation, only the TAK1 binding site in ADAP is necessary for IKK phosphorylation
Sakurai et al., Biochem Biophys Res Commun 1998 : TGF-beta activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase independent mechanism ... A dominant negative mutant of NIK did not inhibit TAK1 induced NF-kappa B activation ... These results suggest that TAK1 induces NF-kappa B activation through a novel NIK independent signaling pathway