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F2 — GNAQ

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: GNAQ → F2 (increases, F2 Activity, GNAQ Activity)
  Evidence: 13,50-52 In the case of some of these agonists, one consequence important for inside-out signaling is activation of phospholipase C-beta by the activated alpha subunit of Gq, resulting in hydrolysis of phosphatidylinositol and production of the second messengers, diacylglycerol and IP3. Mouse platelets that have been rendered null for Gq undergo shape change but fail to aggregate in response to thrombin, ADP, or a thromboxane A2 receptor agonist, and the mice exhibit prolonged tail bleeding time...
• BioCarta activation of pkc through g-protein coupled receptors: Ligand/GPCR/G-alpha-q complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNAQ) → GPCR/G-alpha-q complex (GNAQ) (modification, collaborate)
  
• BioCarta activation of pkc through g-protein coupled receptors: Ligand/GPCR/G-alpha-q complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNAQ) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
  
• BioCarta activation of pkc through g-protein coupled receptors: GPCR/G-alpha-q complex (GNAQ) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
  
• BioCarta g-protein signaling through tubby proteins: ligand/GPCR complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) → GPCR/G-alpha-q/G-beta/G-gamma/TUBBY complex (TUB-GNAQ-GNGT1-GNB1) (modification, collaborate)
  
• BioCarta g-protein signaling through tubby proteins: ligand/GPCR complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) → G-alpha-q/PLC-beta/TUBBY complex (GNAQ-TUB) (modification, collaborate)
  
• BioCarta g-protein signaling through tubby proteins: GPCR/G-alpha-q/G-beta/G-gamma/TUBBY complex (TUB-GNAQ-GNGT1-GNB1) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
  
• BioCarta g-protein signaling through tubby proteins: G-alpha-q/PLC-beta/TUBBY complex (GNAQ-TUB) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
  
• Reactome Reaction: GNAQ → F2 (indirect_complex) Rubio et al., Genomics 1999, Dowal et al., J Biol Chem 2006, Amatruda et al., Proc Natl Acad Sci U S A 1991, Ferguson et al., J Biol Chem 1986, Chen et al., Biochim Biophys Acta 1996
• Reactome Reaction: GNAQ → F2 (reaction) Rubio et al., Genomics 1999, Dowal et al., J Biol Chem 2006, Lambert et al., Science signaling 2008, Amatruda et al., Proc Natl Acad Sci U S A 1991, Ferguson et al., J Biol Chem 1986, Chen et al., Biochim Biophys Acta 1996