Agarwal et al., FASEB J 2003
:
TENS-L is a potent inhibitor of interleukin (IL)-1 beta induced I-kappaBbeta degradation and prevents dissociation of NF-kB from cytoplasmic complexes and thus its nuclear translocation
Kiss et al., J Neurochem 2005
:
IL-1 effectively induced the degradation of inhibitor of NF-kappaBalpha (IkBalpha) and IkBepsilon in both cell types but IkBbeta was not affected Xu et al., Am J Physiol Cell Physiol 2006
(MAP Kinase Signaling System) :
In cultured rat VSMCs, IL-1beta activated ERK and induced degradation of both IkappaBalpha and IkappaBbeta , which was associated with nuclear translocation of both ribosomal S6 kinase (RSK)1 and NF-kappaB p65