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CASP8 — IKBKG
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of CASP8-FADD-IKBKG-RALBP1-TRAF2
→
TNFSF10
(increases)
Varfolomeev et al., J Biol Chem 2005*
Evidence: Here we show that Apo2L/TRAIL activates kinase pathways by promoting the association of a secondary signaling complex, subsequent to assembly of a primary, death-inducing signaling complex (DISC). The secondary complex retained the DISC components FADD and caspase-8, but recruited several factors involved in kinase activation by TNF, namely, RIP1, TRAF2, and NEMO/IKKgamma.
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KEGG RIG-I-like receptor signaling pathway:
Complex of CASP10-CASP8
→
Complex of CHUK-IKBKB-IKBKG
(protein-protein, activation)
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NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Kreuz et al., J Cell Biol 2004
Evidence: mutant phenotype, assay
-
Reactome Reaction:
CASP8
→
IKBKG
(reaction)
Chaudhary et al., Oncogene 2000
-
Reactome Reaction:
CASP8
→
IKBKG
(indirect_complex)
Chaudhary et al., Oncogene 2000
-
WikiPathways RIG-I-like Receptor Signaling:
Complex of CASP8-CASP10
→
Complex of IKBKG-CHUK-IKBKB
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Chen et al., Crit Care Med 2007
(Burns...) :
IKK blocks
caspase 3 expression by up-regulating BCL-xL and cellular FLICE inhibitory protein expression
Frelin et al., Cell Death Differ 2008
:
Inhibition of the NF-kappaB survival pathway via
caspase dependent cleavage of the IKK complex scaffold protein and NF-kappaB essential modulator
NEMO
Oh et al., J Pharmacol Exp Ther 2011
(Inflammation...) :
In activated human mast cells, the receptor interacting protein 2 (RIP2), I?B kinase ( IKK ) -ß, nuclear factor-?B ( NF-?B ) /RelA, and
caspase-1 activation were increased, but increased RIP2,
IKK-ß , NF-?B/RelA, and caspase-1 activation were
inhibited by the treatment of IPT