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RELA — XIAP
Pathways - manually collected, often from reviews:
-
KEGG Apoptosis:
NFKB1/RELA
→
BIRC2/BIRC3/XIAP
(gene expression, expression)
-
KEGG Pathways in cancer:
NFKB1/NFKB2/RELA
→
BIRC2/BIRC3/XIAP
(gene expression, expression)
-
KEGG Small cell lung cancer:
NFKB1/RELA
→
BIRC2/BIRC3/XIAP
(gene expression, expression)
Text-mined interactions from Literome
Verzola et al., J Am Soc Nephrol 2004
(Hyperglycemia) :
At the same time, the expression of
NF-kB induced antiapoptotic
XIAP was reduced in HG-treated cells
Lewis et al., J Biol Chem 2004
:
The
activation of
NF-kappaB by
XIAP was dependent on the E3 ubiquitin ligase activity of the RING domain
Lin et al., J Biol Chem 2004
(Breast Neoplasms) :
Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of
NF-kappaB dependent
XIAP up-regulation
Hentze et al., Hepatology 2004
:
CPT treatment completely abrogated the TNF induced
NF-kappa B activation, and mRNA expression of the antiapoptotic factors TNF-receptor associated factor 2, FLICE-inhibitory protein, and
X-linked inhibitor of apoptosis protein was also
inhibited by CPT. The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ), as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis
Jung et al., Int J Oncol 2004
(MAP Kinase Signaling System) :
The cIAP1, cIAP2 and
XIAP could
enhance the NF-kappaB transcription and the chimeric
NF-kappaB-p65 transactivation
Kim et al., Biochem Biophys Res Commun 2005
(Insulinoma...) :
IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha induced apoptosis by inhibiting
NF-kappaB mediated
XIAP upregulation
Kaur et al., J Biol Chem 2005
(Carcinoma, Hepatocellular) :
We show that
NF-kappaB plays a role in the up-regulation of
XIAP gene expression in response to TGF-beta1 treatment and forms a TGF-beta1-inducible complex with TAK1
Campbell et al., Cancer Res 2006
(Bone Neoplasms...) :
The mechanism through which cisplatin achieves these effects is different to daunorubicin and UV light but shows great similarity to the RelA regulatory pathway induced by the ARF tumor suppressor : cisplatin regulation of
RelA requires ATR/Chk1 activity,
represses Bcl-x ( L ) but not
XIAP expression, and results in phosphorylation of RelA at Thr ( 505 )
Khanbolooki et al., Mol Cancer Ther 2006
(Pancreatic Neoplasms) :
NF-kappaB inhibition
resulted in down-regulation of BCL-XL and
XIAP , and silencing either restored TRAIL sensitivity in TRAIL-resistant cells
Deeb et al., J Pharmacol Exp Ther 2007
(Prostatic Neoplasms) :
Because expression of antiapoptotic Bcl-2, Bcl-xL, and X-chromosome linked inhibitor of apoptosis protein (
XIAP ) is
regulated by
NF-kappaB , both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB
Turner et al., Ann Surg 2007
:
Bile salts induce resistance to apoptosis through
NF-kappaB mediated
XIAP expression ... Specific inhibition of
NF-kappaB by infection with an adenoviral vector that expresses the IkappaBalpha super-repressor ( IkappaBSR )
prevented the induction of
XIAP expression and the bile salt mediated resistance to apoptosis ... These results indicate that bile salts increase intestinal epithelial cell resistance to apoptosis through
NF-kappaB mediated
XIAP expression
Lu et al., Mol Cell 2007
:
XIAP induces
NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization ... In addition to caspase inhibition,
X-linked inhibitor of apoptosis (XIAP)
induces NF-kappaB and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression ... Structure based mutagenesis and knockdown of TAB1 show unambiguously that the BIR1/TAB1 interaction is crucial for
XIAP induced TAK1 and
NF-kappaB activation ... Disruption of BIR1 dimerization abolishes
XIAP mediated
NF-kappaB activation, implicating a proximity induced mechanism for TAK1 activation
Kairisalo et al., Biochem Biophys Res Commun 2007
:
X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through
NF-kappaB activation
Buron et al., Invest Ophthalmol Vis Sci 2008
:
Second, TFF1 interferes with caspase-9 and caspase-3 activation through an
NF-kappaB induced increase in the expression of
XIAP ( X-linked inhibitor of apoptosis protein )
Kim et al., Cancer Lett 2008
:
In addition, treatment of PTX-2 down-regulated
NF-kappaB dependent gene expression, Cox-2, IAP-1, IAP-2 and
XIAP , at the transcriptional and translational level
Bauler et al., PLoS Pathog 2008
(Listeriosis) :
XIAP enhanced
NF-kappaB activation upon L. monocytogenes infection of activated macrophages, and prolonged phosphorylation of Jun N-terminal kinase (JNK) specifically in response to cytosolic bacteria
Kim et al., Frontiers in bioscience (Landmark edition) 2009
(Diabetes Mellitus, Type 1) :
By employing TNF-alpha / IFN-gamma synergism model which causes beta -cell apoptosis, we found that the antiapoptotic X-linked inhibitor of apoptosis (XIAP) molecule is upregulated by
NF-kappaB in response to TNF-alpha and
XIAP induction was
inhibited by IFN-gamma induced signal transducer and activator of transcription-1 ( STAT1 ) activation, which explains the death of beta -cells by TNF-alpha /IFN-gamma synergism
Ottonello et al., Br J Pharmacol 2009
:
Consistently, the inhibition of
NF-kappaB activation
reduced the production of the anti-apoptotic molecule
XIAP , leading to uncontrolled activity of caspase 3
Kim et al., Arch Pharm Res 2009
(Colonic Neoplasms) :
NF-kappaB target gene expression of apoptotic cell death proteins ( Bax, caspase-3, caspase-9 ) was significantly enhanced, but the expression of anti-apoptotic genes and cell proliferation marker genes ( Bcl-2, inhibitor of apoptosis protein ( IAP-1 ) and
X chromosome IAP (XIAP) , Cox-2, c-Fos, c-Jun and cyclin D1 ) was significantly
inhibited by the combined treatment compared to Rg3 or docetaxel alone
Banerjee et al., Cancer Res 2009
(Pancreatic Neoplasms) :
Our data provide mechanistic evidence for the first time showing that DIM potentiates the killing of pancreatic cancer cells by down-regulation of constitutive as well as drug induced
activation of
NF-kappaB and its downstream genes ( Bcl-xL,
XIAP , cIAP, and survivin )
Momeny et al., Med Oncol 2010
:
Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of
NF-kappaB mediated induction of
XIAP , cIAP2, BCL-XL and survivin ... Altogether, these issues show for the first time that ATO treatment could trammel cell growth and proliferation as well as induces apoptosis in NB-4 cells through induction of transcriptional levels of p73, TP53INP1, WNK2, lipocalin 2 as well as suppression of
NF-kappaB mediated
induction of BCL-X ( L ), cIAP2,
XIAP and survivin
Kwon et al., Biochem Biophys Res Commun 2010
(Neoplasms) :
Furthermore, expression of
NF-kappaB dependent genes, FLICE-inhibitory protein (FLIP), inhibitor of apoptosis protein 1 ( c-IAP1 ), or
X-linked inhibitor of apoptosis protein ( XIAP ) was reduced in TOPK depleted cells
Mehrotra et al., Cancer Cell 2010
(Neoplasm Invasiveness) :
Instead, a
survivin-XIAP complex
activates NF-kappaB , which in turn leads to increased fibronectin gene expression, signaling by beta1 integrins, and activation of cell motility kinases FAK and Src
Wang et al., Microb Pathog 2010
:
Because expressions of anti-apoptotic Bcl-2, survivin, inhibition of apoptosis protein ( cIAP ), and X-chromosome linked inhibitor of apoptosis protein (
XIAP ) are
regulated by
NF-kappaB , S. aureus decreased the levels of these proteins in U937 cells through inhibition of NF-kappaB