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IRS1 — NOS2
Text-mined interactions from Literome
Sugita et al., J Biol Chem 2005
:
Inducible
nitric-oxide synthase and NO donor
induce insulin receptor substrate-1 degradation in skeletal muscle cells ... These findings indicate that
iNOS reduces
IRS-1 expression in skeletal muscle via proteasome mediated degradation and thereby may contribute to obesity related insulin resistance
Fujimoto et al., Diabetes 2005
(Diabetes Mellitus, Type 2...) :
iNOS inhibitor also increased the protein expression of insulin receptor substrate (IRS)-1 and -2 1.5- and 2-fold, respectively, and
enhanced IRS-1- and IRS-2 mediated insulin signaling in the liver of ob/ob mice
Xu et al., Mol Endocrinol 2007
(Insulin Resistance...) :
Recombinant CRP suppressed insulin induced NO production,
inhibited the phosphorylation of Akt and endothelial
nitric oxide synthase , and stimulated the phosphorylation of
IRS-1 at the Ser307 site in a dose dependent manner