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LIMK2 — PAK2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Misra et al., J Biol Chem 2005
(Neoplasm Metastasis) :
Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates
PAK-2 dependent
activation of
LIMK ... Silencing the expression of the
PAK-2 gene greatly
attenuated the phosphorylation of
LIMK
Thirone et al., Am J Physiol Cell Physiol 2009
:
Hyperosmolarity provoked cofilin phosphorylation was mediated by the Rho/Rho kinase ( ROCK ) /LIM kinase ( LIMK ) but not the Rac/PAK/LIMK pathway, because 1 ) dominant negative ( DN ) Rho and DN-ROCK but not DN-Rac and DN-PAK inhibited cofilin phosphorylation ; 2 ) constitutively active ( CA ) Rho and CA-ROCK but not CA-Rac and
CA-PAK induced cofilin phosphorylation ; 3 ) hyperosmolarity induced LIMK-2 phosphorylation, and 4 ) inhibition of ROCK by Y-27632
suppressed the hypertonicity triggered
LIMK-2 and cofilin phosphorylation.We thenexamined whether cofilin and its phosphorylation play a role in the hypertonicity triggered F-actin changes ... Hyperosmolarity provoked cofilin phosphorylation was mediated by the Rho/Rho kinase ( ROCK )
/LIM kinase ( LIMK ) but not the Rac/PAK/LIMK pathway, because 1 ) dominant negative ( DN ) Rho and DN-ROCK but not DN-Rac and DN-PAK inhibited cofilin phosphorylation ; 2 ) constitutively active ( CA ) Rho and CA-ROCK but not CA-Rac and
CA-PAK induced cofilin phosphorylation ; 3 ) hyperosmolarity induced LIMK-2 phosphorylation, and 4 ) inhibition of ROCK by Y-27632 suppressed the hypertonicity triggered LIMK-2 and cofilin phosphorylation.We thenexamined whether cofilin and its phosphorylation play a role in the hypertonicity triggered F-actin changes