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IFNG — LRPAP1

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Altmeyer et al., Cytokine 1993 : Moreover, kinetics analysis revealed that RAP still inhibited IFN-gamma mRNA accumulation in YAC-1 cells, when added as late as 12-18 h after initial stimulation of the cells with IL-1 alpha + PMA
Dumont et al., J Cell Physiol 1994 (Lymphoma, T-Cell) : Here, we found that when induced by IL-1 or IL-1 + PMA, the production of IFN-gamma is suppressed by both TGF-beta 1 ( ED50 = 1.9 pM ) and RAP ( ED50 = 0.2 nM ) ... Hence, the up-regulation of IFN-gamma production by TGF-beta 1 and RAP may involve a different biochemical mechanism than that mediating their suppressive action
Dumont et al., J Immunol 1994 (Lymphoma, T-Cell) : Rapamycin (RAP) inhibits several biologic responses in the YAC-1 T cell lymphoma, including the serum-driven proliferation and cyclin A mRNA expression, the induction of Ly-6E Ag expression by IFN, and the induction of IFN-gamma production by IL-1 ... Two other mutant types, R103 and R125, were both highly sensitive to RAP mediated suppression of proliferation, of IL-1 induced IFN-gamma production, and of pp70s6k activity but differed in their Ly-6E response ... Therefore, the inhibitory effects of RAP on proliferation and IL-1 mediated IFN-gamma induction both appear associated with the inhibition of pp70s6k activity, whereas the modulation of Ly-6E induction is independent from the latter