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IRF6 — RHOA
Text-mined interactions from Literome
Schmeck et al., Inflammation 2003
:
Therefore,
RhoA/Rac1/Cdc42 contribute to NF-kappaB dependent
LPS- and TNFalpha induced expression of PGHS-2 in EC but had no effect on the activity of expressed COX-1 and COX-2
Pomorski et al., Cell Motil Cytoskeleton 2004
:
LPS suppressed
Rho A activity and either this agent or C3 transferase elevated intracellular free calcium, stabilized transcripts, and, in tandem, inhibited cell migration by preventing tail retraction, a prerequisite for cell translocation
Kamon et al., EMBO J 2006
:
LPS increased the activity of RhoB, but not of
RhoA , Cdc42, or Rac1/2 in a manor dependent on LPS-TRIF- but not LPS-Myd88 signaling
Shimizu et al., Mol Hum Reprod 2007
:
Pull-down assays showed that
LPS activated
RhoA , but IL-1beta caused only a lower level of activation
Polk et al., Am J Physiol Cell Physiol 2007
(Nephritis) :
Conversely, constitutive expression of
RhoA prevented NF-kappaB activation by
LPS , and this effect was reversed by cotransfection with MEKK1-KD
Soliman et al., Cardiovasc Res 2008
(Diabetes Mellitus, Experimental...) :
Both SNP and
LPS increased
RhoA expression in non-diabetic cardiomyocytes
Toguchi et al., Neurochem Int 2009
:
We also provide evidence that
LPS markedly upregulated Plexin-B1 expression in microglia and Sema4D/CD100
stimulated RhoA-activation in LPS activated microglia
Mambetsariev et al., Arterioscler Thromb Vasc Biol 2010
(Acute Lung Injury...) :
Silencing protease activated receptor 1 and 3,
RhoA , or Rho kinase expression
attenuated LPS- , LMW-HA-, and HABP2 mediated EC barrier disruption
He et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010
:
LPS activated
RhoA and NF-?B at 0.5 h ...
LPS induces the disruption of F-actin cytoskeleton and brain microvascular endothelial barrier integrity, in part, through
RhoA and NF-?B activation
Yao et al., Biochim Biophys Acta 2011
(Lung Injury) :
LPS activated both Rac1 and Rac2, but not CDC42 or
RhoA activities in lungs, and specific inhibition of Rac activities by NSC23766 effectively alleviated LPS induced injury