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RELA — SERPINE1
Text-mined interactions from Literome
Dechend et al., Circulation 1999
(Arteriosclerosis) :
Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates
NF-kappaB and
induces tissue factor and
PAI-1 expression : a potential link to accelerated arteriosclerosis
Maeda et al., J Biol Chem 2001
(Stomach Neoplasms) :
In conclusion, H. pylori induced
NF-kappaB activation in epithelial cells is
dependent on cag
PAI and contact but does not involve CD14 and IRAK, whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4
Philpott et al., Cell Microbiol 2002
(Disease Models, Animal...) :
Six isolates were shown to harbour a complete cag
PAI and to
induce NF- kappa B activation and IL-8 secretion in AGS cells
Hamaguchi et al., J Pharmacol Exp Ther 2003
:
A protein tyrosine kinase inhibitor, genistein, completely inhibited TNF-alpha induced PAI-1 secretion, whereas an inhibitor of extracellular signal regulated kinase ( ERK ) kinase, 2'-amino-3'-methoxyflavone ( PD98059 ), and a
nuclear factor-kappaB (NF-kappaB) inhibitor, emodin, partly
inhibited TNF-alpha induced
PAI-1 secretion
Li et al., Kidney Int 2005
(Anoxia) :
Inhibition of
nuclear factor-kappaB (NF-kappaB) caused a moderate decrease in
PAI-1 production under hypoxia
Swiatkowska et al., FEBS J 2005
:
We show that activation of
PAI-1 gene by TNFalpha and reactive oxygen species is
mediated by interaction of
NF-kappaB with the cis acting element located in the -675 4G/5G insertion/deletion in the PAI-1 promoter
Iwasaki et al., Atherosclerosis 2008
(Hyperglycemia) :
NF-kappaB activity determined using the luciferase reporter gene assay was significantly enhanced by high glucose, and pretreatment with Y-27632
inhibited high glucose induced
PAI-1 expression at the basal level ... An inhibitor of
NF-kappaB action, namely parthenolide ( 0.1 microM ), BAY 11-7082 ( 5 microM ) and SN50 ( 1 microM ), significantly
blocked high glucose mediated
PAI-1 expression to a level with low glucose ( 5.7 mM ) ... These data suggested that high glucose induced
PAI-1 expression in endothelial cells is
mediated by
NF-kappaB activation through the Rho/Rho-kinase pathway
Vaziri et al., J Pharmacol Exp Ther 2007
(Disease Models, Animal...) :
The untreated group exhibited hypertension, deterioration of renal function and structure, reduced or unchanged plasma renin activity, aldosterone concentration, marked up-regulations of AT1r ( 250 % ), Ang II-expressing cell count ( > 20-fold ), NAD ( P ) H oxidase subunits ( gp91(phox,) p22(phox), and P47 ( phox ) ; 20-40 % ), COX-2 ( 250 % ), 12-lipooxygenase ( 100 % ), MCP-1 ( 400 % ), and
PAI-1 ( > 20-fold ),
activation of
NFkappaB , and interstitial infiltrations of T cells and macrophages in the remnant kidneys
Laumen et al., Atherosclerosis 2008
:
In conclusion our data suggest that rosuvastatin inhibits
PAI-1 expression and release from human adipocytes via a MEKK-1 dependent but not a
NFkappaB dependent mechanism
Collins-Underwood et al., Free Radic Biol Med 2008
:
We report that irradiating rat brain microvascular endothelial cells in vitro leads to increased ( i ) intracellular ROS generation, ( ii )
activation of the transcription factor
NFkappaB , ( iii ) expression of ICAM-1 and
PAI-1 , and ( iv ) expression of Nox4, p22(phox), and p47(phox) ... Pharmacologic and genetic inhibition of NADPH oxidase blocked the radiation mediated upregulation of intracellular ROS,
activation of
NFkappaB , and upregulation of ICAM-1 and
PAI-1
Takeshima et al., BMC microbiology 2009
(Helicobacter Infections) :
The inflammatory response in Helicobacter pylori infected gastric tissue is mediated by cag
pathogenicity island (PAI) dependent activation of
nuclear factor-kappaB (NF-kappaB)