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RELA — SERPINF1

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Yamagishi et al., J Mol Cell Cardiol 2004 : Accordingly, we investigated effects of PEDF on reactive oxygen species ( ROS ) generation, NF-kappaB activation and interleukin (IL)-6 expression in TNF-alpha exposed HUVEC ... PEDF or an antioxidant, N-acetylcysteine, significantly inhibited the TNF-alpha induced NF-kappaB activation ... The results demonstrated that PEDF inhibited TNF-alpha induced NF-kappaB activation and subsequent IL-6 overexpression in HUVEC by suppressing NADPH oxidase mediated ROS generation
Yoshida et al., Life Sci 2006 : PEDF blocked the IL-6 induced STAT3 phosphorylations and NF-kappaB p65 activity in Hep3B cells
Yamagishi et al., Ophthalmic Res 2007 (Diabetes Mellitus, Experimental...) : In addition, PEDF completely inhibited superoxide generation and NF-kappaB activation in AGE exposed endothelial cells
Wang et al., American journal of physiology. Renal physiology 2008 (Diabetes Mellitus, Experimental...) : Furthermore, PEDF inhibited high glucose induced activation of NF-kappaB , a key transcription factor mediating inflammatory responses, and hypoxia-inducible factor-1, a major activator of VEGF expression in HMC
Zhang et al., J Mol Endocrinol 2008 (Inflammation) : PEDF also attenuated the HOG-LDL induced NF-kappaB activation, suggesting that the inhibitory effect of PEDF on MCP-1 was at least partially through the blockade of NF-kappaB activation
Ide et al., Microvasc Res 2010 (Diabetic Nephropathies) : PEDF or neutralizing antibody raised against RAGE ( receptor for AGE ) was found to inhibit the AGE induced oxidative stress generation and subsequent NF-kappaB activation in mesangial cells