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SMPD1 — TNFRSF1A

Pathways - manually collected, often from reviews:

• NCI Pathway Database Ceramide signaling pathway: TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF) → Acid Sphingomyelinase (SMPD1) (modification, activates)
  Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
  Evidence: assay, physical interaction
• NCI Pathway Database Ceramide signaling pathway: TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF) → Acid Sphingomyelinase (SMPD1) (modification, activates)
  Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: TNFRSF1A — SMPD1 (colocalization, fluorescence microscopy) Edelmann et al., EMBO J 2011*

Text-mined interactions from Literome

Chatterjee et al., Mol Carcinog 2001 : Fas receptor and tumor necrosis factor receptor-1 (TNFR1) mediate the activation of acid sphingomyelinase (ASMase) , which catalyzes the hydrolysis of sphingomyelin to ceramide
Church et al., J Leukoc Biol 2005 (Calcium Signaling) : The engagement of TNFR1 by TNF-alpha led to a time dependent increase in acid sphingomyelinase ( SMase ; ASM ) activity, corresponding with a decrease in cellular sphingomyelin