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CDKN2B — HDAC3

Text-mined interactions from Literome

Huang et al., Biochem Biophys Res Commun 2006 : Histone deacetylase 3 represses p15(INK4b) and p21 ( WAF1/cip1 ) transcription by interacting with Sp1 ... Here we demonstrated that the overexpression of HDAC3 repressed transcription of p15(INK4b) and p21 ( WAF1/cip1 ) genes in 293T cells, and that the recruitment of HDAC3 to the promoter regions of these genes was critical to this repression ... We conclude that HDAC3 can repress p15(INK4b) and p21 ( WAF1/cip1 ) transcription by interacting with Sp1
Scott et al., Exp Hematol 2007 (Acute Disease...) : We observed enhanced p15INK4B induction following co-treatment with zebularine and the histone deacetylase inhibitor Trichostatin A. Zebularine inhibits cell proliferation, arrests cells at G ( 2 ) /M, and induces apoptosis at dosages that effectively demethylate the p15INK4B promoter