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ARF6 — RHOA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Arf6 downstream pathway:
ARF6/GTP complex (ARF6)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Boshans et al., Mol Cell Biol 2000*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Arf6 downstream pathway:
ARF6/GTP complex (ARF6)
→
RHOA/GTP complex (RHOA)
(modification, activates)
Boshans et al., Mol Cell Biol 2000*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Class I PI3K signaling events:
RHOA/GDP complex (RHOA)
→
ARF6/GDP complex (ARF6)
(actin cytoskeleton reorganization, activates)
Krugmann et al., J Cell Sci 2006*, Hawkins et al., Curr Biol 1995*
Evidence: mutant phenotype
Text-mined interactions from Literome
Yamazaki et al., J Biol Chem 1999
:
Finally, we show that recombinant D4 peptide inhibits
RhoA stimulated PLD1 activation but not
ARF- or PKC-alpha stimulated PLD1 activation
Houle et al., J Leukoc Biol 1999
:
Whereas fMLP recruited all three proteins to membranes, V4+-OOH only elicited
RhoA translocation and PMA
induced ARF and PKCalpha translocation