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E2F1 — FGFR1

Text-mined interactions from Literome

Parakati et al., Dev Dyn 2005 : Upon overexpression, E2F4 repressed FGFR1 promoter activity in a dose dependent manner in myoblasts and Drosophila SL2 cells, and mutation of the E2F4 binding site increased FGFR1 promoter activity and reduced E2F4 mediated repression
Kanai et al., Gene 2009 : Transcriptional regulation of human fibroblast growth factor receptor 1 by E2F-1 ... Furthermore, we show that the expression of human FGFR 1 is regulated by E2F-1 ... Characterization of the human FGFR 1 promoter demonstrated that two non-consensus E2F binding sequences at positions +4 to +22 and +25 to +43 relative to our identified transcriptional initiation site in the human FGFR 1 gene were critical for E2F-1 mediated transactivation of human FGFR 1 promoter ... Mutations of these sites completely abolished the response of human FGFR 1 promoter to E2F-1 as well as E2F-1 binding in electrophoretic mobility-shift assays ... Moreover, human FGFR 1 protein expression was up-regulated by the overexpression of E2F-1 , but down-regulated by the overexpression of pRB in situ, suggesting that the expression of human FGFR 1 is regulated by the pRB/E2F pathway