◀ Back to MAPK12
MAPK12 — TAB1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
McDermott et al., J Biol Chem 2002
:
In addition we found a
role for
TAK-1 in the activation of p38
MAPK by IL-1, with TAK-1 also associating with active Ras
Makeeva et al., International journal of biological sciences 2007
:
The aim of present study was to elucidate the
role of
TAB1 in nitric oxide induced activation of p38
MAPK
Kim et al., American journal of physiology. Renal physiology 2007
:
TGF-beta activated kinase 1 and
TAK1 binding protein 1 cooperate to
mediate TGF-beta1 induced MKK3-p38
MAPK activation and stimulation of type I collagen
Windheim et al., Biochem J 2007
:
We also show that RIP2
induces the activation of the protein kinase
TAK1 ( transforming-growth-factor-beta activated kinase-1 ), that a dominant negative mutant of TAK1 inhibits RIP2 induced activation of JNK ( c-Jun N-terminal kinase ) and p38alpha
MAPK , and that signalling downstream of NOD2 or RIP2 is reduced by the TAK1 inhibitor ( 5Z ) -7-oxozeaenol or in TAK1-deficient cells
Makeeva et al., Endocrinology 2008
:
Transforming growth factor-beta activated protein kinase 1-binding protein (
TAB)-1alpha , but not TAB1beta,
mediates cytokine induced p38
mitogen activated protein kinase phosphorylation and cell death in insulin producing cells ... Transforming growth factor-beta activated protein kinase 1-binding protein ( TAB)-1alpha, but not
TAB1beta ,
mediates cytokine induced p38
mitogen activated protein kinase phosphorylation and cell death in insulin producing cells
Mendoza et al., Biochem J 2008
:
Studies using TAB1 ( -/- ) MEFs indicate important
roles for
TAB1 in recruiting p38alpha
MAPK to the TAK1 complex for the phosphorylation of TAB3 at Ser ( 60 ) and Thr ( 404 ) and in inhibiting the dephosphorylation of TAB3 at Ser ( 506 )
Kodym et al., RNA 2008
(MAP Kinase Signaling System) :
Activation of
TAK1-D leads to the downstream activation of the p38
MAPK and of SAPK/JNK but not the NFkappaB pathway
Mikkelsen et al., J Biol Chem 2009
:
We also observed that TRAF2 and
TAK1 were
essential for RIG-I mediated activation of p38
MAPK
Cheng et al., J Biomed Mater Res A 2010
(Inflammation...) :
The critical
role for
TAK1 in
p38MAPK and NFkappaB activation was as well confirmed by the inhibition of p38MAPK and NFkappaB activity following 5Z-7-oxozeaenol, a selective inhibitor of TAK1
Wolf et al., PloS one 2011
:
The TAB1 mutant lacking aa 452-457 decreases
TAB1 dependent phosphorylation of p38
MAPK
Tran et al., J Biol Chem 2012
(MAP Kinase Signaling System) :
In agreement with this, overexpression of ASK1 or
TAK1 resulted in enhanced
p38MAPK activation, and their knockdown inhibited p38MAPK in C2C12 cells
Yumoto et al., J Biol Chem 2013
(Cleft Palate) :
Our studies show that in neural crest derived craniofacial ecto-mesenchymal cells,
Tak1 is not only
required for TGF-ß- and bone morphogenetic protein induced p38
Mapk activation but also plays a role in agonist induced C-terminal and linker region phosphorylation of the receptor mediated R-Smads