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IL12B — WAS
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Newton et al., J Leukoc Biol 2004
(Legionnaires' Disease) :
The results showed that RU486 did not attenuate the
THC induced suppression of serum
interleukin (IL)-12 or interferon-gamma (IFN-gamma) ... Although L. pneumophila infection increased urinary PGE2, THC pretreatment did not enhance this response ; in addition, treatment with the cyclooxygenase inhibitor, indomethacin, did not block the
THC induced suppression of
IL-12 and IFN-gamma
Lu et al., Eur J Pharmacol 2006
:
These results suggest that
THC induced suppression of serum
IL-12 is partly due to a suppression of IL-12 production by dendritic cells and that G ( i ) signaling and cannabinoid receptors, but not TRPV1, are involved in this suppressive effect
Newton et al., Adv Exp Med Biol 1998
:
It was found that
THC suppressed
IL-12 , IL-15 and IL-6 and increased IL-1 alpha, IL-1 beta, and TNF alpha in all of the stimulated cultures