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PARP1 — STK11

Text-mined interactions from Literome

Mathews et al., Arterioscler Thromb Vasc Biol 2008 : PARP-1 inhibition can also activate the prosurvival serine/threonine kinase , Akt
Pacurari et al., Environ Health Perspect 2008 (Neoplasms, Mesothelial) : In the present study, we exposed mesothelial cells to SWCNTs and investigated reactive oxygen species ( ROS ) generation, cell viability, DNA damage, histone H2AX phosphorylation, activation of poly(ADP-ribose) polymerase 1 ( PARP-1 ), stimulation of extracellular signal regulated kinase ( ERKs ), Jun N-terminal kinases (JNKs), protein p38, and activation of activator protein-1 (AP-1), nuclear factor kappaB (NF-kappaB), and protein serine-threonine kinase ( Akt )
Son et al., Toxicol Appl Pharmacol 2011 : Consequently, these results suggest that cadmium mediated ROS generation causes PARP activation and energy depletion, and eventually induces autophagy through the activation of LKB1-AMPK signaling and the down-regulation of mTOR in skin epidermal cells