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IL17A — NOS3
Text-mined interactions from Literome
Liu et al., J Immunol 2012
(Vascular Diseases) :
Induction of endothelial
nitric oxide synthase expression by
IL-17 in human vascular endothelial cells : implications for vascular remodeling in transplant vasculopathy ... We have examined the
role of
IL-17 in regulating
endothelial NO synthase (eNOS) expression in human vascular endothelial cells ( ECs ) because of the key role of eNOS in determining the pathological outcome of immune mediated vascular diseases ... In cultured ECs,
IL-17 increased expression of
eNOS , eNOS phosphorylation at Ser ( 1177 ), and NO production ... The
induction of
eNOS expression by
IL-17 was prevented by the pharmacological inhibition of NF-?B, MEK, and JNK, as well as by small interfering RNA mediated gene silencing of these signaling pathways ... Altogether, these findings show that
IL-17 induces the expression of
eNOS in human ECs and that this may facilitate outward expansion of arteries afflicted with TV
Nguyen et al., Cardiovasc Res 2013
(Hypertension) :
In isolated mouse aortas,
IL-17 significantly
increased eNOS Thr495 phosphorylation, induced RhoA expression, and decreased NO-dependent relaxation responses, all of which were prevented by either an IL-17 neutralizing antibody or inhibition of Rho-kinase