Zhu et al., J Steroid Biochem Mol Biol 2004
(MAP Kinase Signaling System) :
This effect may be associated with the decreased expression of p27 , the increased expression of PKC-alpha, and the activation of NF-kappaB Yamauchi et al., Int Immunol 2007
(Genetic Predisposition to Disease...) :
Thus, Ifi202 is an important NF-kappaB activator in DCs and involved in IL-12 production, which may account for a T ( h ) 1-prone phenotype of BWF1 mice
Batsi et al., Biochem Pharmacol 2009
:
Interestingly, NF-kappaB activity and p50 levels were increased by 2-ME2 and suppression of NF-kappaB signaling reduced p27 ( Kip1 ) expression and sensitized cells to 2-ME2 induced apoptosis