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MAPK15 — RUNX2

Text-mined interactions from Literome

Pei et al., Acta Pharmacol Sin 2003 (MAP Kinase Signaling System) : And mitogen activated protein kinase ( MAPK ) inhibitor, PD 98059 ( 10 micromol/L ), completely blocked IGF-1, GM-CSF, and EGF induced expression of Cbfa1 promoter activity ( P < 0.01 )
Celil et al., J Biol Chem 2005 : PKC/D and MAPK signaling also mediate Runx2 activity
Kanno et al., J Cell Biochem 2007 (MAP Kinase Signaling System) : Mechanical stress mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts ... We examined the involvement of diverse mitogen activated protein kinase ( MAPK ) pathways in the activation of Runx2 during mechanical stress
Franceschi et al., Ann N Y Acad Sci 2007 : MAPK activation of RUNX2 was also found to occur in vivo
Lee et al., J Bone Miner Res 2008 : Taken together, these findings indicate that BBR promotes osteoblast differentiation through activation of Runx2 by p38 MAPK
Rasheed et al., Arthritis Res Ther 2010 (Osteoarthritis) : In this study we determined the effect of a standardized pomegranate extract ( PE ) on the IL-1ß induced activation of MKK3/6, p38-MAPK isoforms and the activation of transcription factor RUNX-2 in primary human OA chondrocytes
Ge et al., J Bone Miner Res 2012 (MAP Kinase Signaling System) : Significantly, in the presence of AA, BMP2/7 synergistically stimulated RUNX2 S319 phosphorylation and transcriptional activity without affecting total RUNX2 and this response was totally dependent on ERK/MAPK activity
Li et al., J Bone Miner Res 2012 : These findings establish ERK/MAPK mediated phosphorylation of RUNX2 as a critical step in the response of preosteoblasts to dynamic loading and define a novel mechanism to explain how mechanical signals induce gene expression in bone
Yue et al., Biochim Biophys Acta 2013 : Similar results were obtained in experiments performed in the native tissue in which inhibition of ERK and p38 MAPK increased BK channel activity in the cortical collecting duct (CCD) treated with dynasore