Wang et al., Cell Death Differ 2006
:
RA/BDNF treatment activates Cdk5 mediated PI3K/Akt and ERK pathways ... Inhibition of Cdk5 inhibits PI3K/Akt and ERK phosphorylation and Bcl-2 expression, and thus sensitizes the differentiated cells to DNA-damage
Liu et al., Proc Natl Acad Sci U S A 2008
(Central Nervous System Neoplasms...) :
Growth signal activates Cdk5 and results in a Cdk5 dependent accumulation of phosphorylated PIKE-A and activation of Akt in the nucleus