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AKT3 — HRG
Text-mined interactions from Literome
Lee et al., Cancer Res 2001
(Breast Neoplasms) :
p85-sErbB3 inhibits HRG induced phosphorylation of ErbB2, ErbB3, and ErbB4 in breast carcinoma derived cell lines and can also block
HRG stimulated activation of mitogen activated protein kinase,
Akt , and association of ErbB3 with the phosphatidylinositol 3'-kinase p85 regulatory subunit
Stoica et al., Oncogene 2003
:
Akt phosphorylation by HRG-beta1 was abrogated by an arginine to cysteine mutation ( R25C ) in the pleckstrin homology (PH) domain of Akt, and
HRG-beta1 did not
induce Akt phosphorylation in the ER-negative variant of MCF-7, MCF-7/ADR ...
HRG-beta1 did not
activate Akt in MCF-7 cells stably transfected with an anti-ErbB2 targeted ribozyme, further confirming a role for ErbB2
Cantó et al., J Biol Chem 2004
:
In L6E9 myotubes,
HRG stimulated PKBalpha,
PKBgamma , and PKCzeta activities
Xia et al., Oncogene 2004
(Breast Neoplasms) :
Increased phosphorylation of p95ErbB2 and
AKT in
response to
HRG was abrogated to varying degrees by GW572016
Gui et al., Mol Cell Biochem 2007
:
Akt and ERK were
activated by
HRG under SD and hypoxia conditions, but HRG had no effects on the activation of JNK and p38
Sakai et al., Cancer Sci 2007
(Carcinoma, Non-Small-Cell Lung...) :
Pertuzumab blocked
HRG-alpha stimulated phosphorylation of HER3, mitogen activated protein kinase ( MAPK ), and
Akt
Ou et al., Carcinogenesis 2008
(Ovarian Neoplasms) :
We also elucidate that
heregulin (HRG) specifically restores the activation of p185 and
Akt after their activities are
reduced by RIG1
Zhang et al., Cancer Lett 2008
(Breast Neoplasms) :
HRG induced
AKT activation was attenuated in EBP1 stable transfectants and transfection of a constitutively activated AKT partially restored the growth response to HRG
Zhang et al., Mol Cancer Ther 2008
(Disease Models, Animal...) :
The ability of the ErbB3 ligand
heregulin (HRG) to
stimulate growth and
AKT phosphorylation of hormone-refractory prostate cancer cells was abolished
Yonezawa et al., Digestion 2009
(Adenocarcinoma...) :
HRG also
activated p85 PI-3K,
Akt , ERK1/2, and p38 MAPK
Cho et al., Mol Med Report 2008
:
The present results suggest that
Akt and MAPK
mediate HRG-ß1 signaling to MMP-9