◀ Back to SMAD3
PTHLH — SMAD3
Text-mined interactions from Literome
Pateder et al., J Cell Physiol 2001
:
Co-transfection of the TGF-beta signaling molecule, Smad 3, mimicked the effect of TGF-beta ( induction of PTHrP promoter ), while dominant negative
Smad 3 inhibited the induction of the
PTHrP promoter by TGF-beta ... In contrast, a dominant negative
Smad 3 completely
inhibited PTHrP promoter stimulation by TGF-beta, but only partially blocked the effect of TGF-beta on PTHrP mRNA synthesis
Kakonen et al., J Biol Chem 2002
(Bone Neoplasms...) :
Stable transfection of wild-type Smad2, Smad3, or Smad4 increased TGF-beta stimulated PTHrP secretion, whereas dominant negative Smad2,
Smad3 , or Smad4 only partially
reduced TGF-beta stimulated
PTHrP secretion
Lindemann et al., Biochem J 2003
(Breast Neoplasms...) :
In invasive MDA-MB-231 breast cancer cells, transforming growth factor beta regulated PTHrP synthesis is mediated by an
Ets1/Smad3 dependent activation of the
PTHrP P3 promoter
Cao et al., Regul Pept 2013
:
We found that ( 1 ) TGF-ß induces PTHrP mRNA expression, protein expression and secretion in a time dependent fashion ; ( 2 ) knockdown of PTHrP gene expression or neutralization of secreted PTHrP isoforms blocks TGF-ß induced apoptosis ; and ( 3 ) TGF-ß induced
PTHrP expression is
Smad3 dependent