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AGT — IL6

Text-mined interactions from Literome

Sherman et al., Mol Endocrinol 2001 (Carcinoma, Hepatocellular...) : Role of signal transducers and activators of transcription 1 and -3 in inducible regulation of the human angiotensinogen gene by interleukin-6
Ray et al., Mol Endocrinol 2002 : Recently we showed that IL-6 induces human ( h ) AGT transcription by activating the signal transducers and activators of transcription ( STATs )
Ray et al., Gastroenterology 2005 (Acute-Phase Reaction...) : STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen
Jain et al., Am J Physiol Cell Physiol 2007 (Carcinoma, Hepatocellular...) : HNF-1alpha plays an important role in IL-6 induced expression of the human angiotensinogen gene ... AGT is an acute phase protein and its gene expression is regulated by IL-6
Satou et al., American journal of physiology. Renal physiology 2008 : This study was performed in human renal proximal tubular epithelial cells ( HRPTECs ) to test the hypothesis that IL-6 contributes to the upregulation of AGT expression by ANG II
Satou et al., Mol Cell Endocrinol 2009 : IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells ... Therefore, the present study was performed to elucidate the effects of IL-6 on AGT expression in primary cultured human renal proximal tubular epithelial cells ( RPTEC ) after characterization of HK-2 and RPTEC
Lai et al., PloS one 2013 : Primary cultures of mouse hepatocytes were used to investigate IL-6 induced angiotensinogen ... In the in vitro model, IL-6 transcriptionally regulated angiotensinogen expression ... Additionally, IL-6 mediated angiotensinogen expression through the Janus kinase ( JAK ) /signal transducer and activator of transcription 3 ( STAT3 ) and JAK/p38 signaling ... Decoy ODN analyses revealed that STAT3 and nuclear factor-kB (NF-kB) also played critical roles in the transcriptional regulation of angiotensinogen by IL-6 ... IL-6 mediated signaling, JAK2, STAT3 and p38 inhibitors reduced angiotensinogen expression in the partially hepatectomized mice
Soden et al., Hypertension 1994 (Inflammation) : A similar inhomogeneity was found in an additional experiment performed to analyze the direct effects of interleukin-1 or interleukin-6 on the secretion of angiotensinogen by freshly isolated hepatocytes
Takano et al., Biochem Pharmacol 1993 (Inflammation) : These results suggest that increased synthesis of angiotensinogen in the liver after induction of inflammation is mediated by IL-6 , a cytokine important in immune reactions and the hepatic acute-phase response