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EPHB2 — F2RL1

Text-mined interactions from Literome

DeFea et al., J Cell Biol 2000 : In contrast, a mutant PAR2 ( PAR2deltaST363/6A ), which is unable to interact with beta-arrestin and, thus, does not desensitize or internalize, activates ERK1/2 by a distinct pathway, and fails to promote both complex formation and cytosolic retention of the activated ERK1/2 ... Thus, formation of a signaling complex comprising PAR2, beta-arrestin, raf-1, and activated ERK1/2 might ensure appropriate subcellular localization of PAR2 mediated ERK activity, and thereby determine the mitogenic potential of receptor agonists
Kim et al., Cell Biochem Funct 2002 (Astrocytoma) : These results show that trypsin may induce TNF-alpha secretion following activation of ERK and p38 via PAR2 in CCF-STTG1
Darmoul et al., J Biol Chem 2004 (Colonic Neoplasms) : By using the Src tyrosine kinase inhibitor PP2, we further showed that Src plays a permissive role for PAR2 mediated ERK1/2 activation and cell proliferation, probably acting downstream of the EGF-R
Stalheim et al., Mol Pharmacol 2005 : Moreover, activated PAR2 caused rapid and prolonged activation of endogenous extracellular signal regulated kinase ( ERK1/2 )
Nishibori et al., J Pharmacol Sci 2005 (Colonic Neoplasms) : PAR-2 stimulation induced the phosphorylation of MEK1/2 and ERK1/2 , but PAR-1 stimulation did not
Tanaka et al., Kidney Int 2005 : There results suggest that factor Xa can induce mesangial cell proliferation through the activation of ERK via PAR2 in mesangial cells and that PAR2 may play a crucial role in the cell proliferation induced by factor Xa
Jacob et al., J Biol Chem 2005 : Down-regulation of beta-arrestins with small interfering RNA inhibited PAR2 induced activation of ERK1/2 and suppressed PAR2 induced changes in permeability
Chokki et al., FEBS J 2005 : Both HAT and PAR-2 agonist peptide (PAR-2 AP) induced ERK phosphorylation ; further, desensitization of PAR-2 with a brief exposure of cells to PAR-2 AP resulted in inhibition of HAT induced ERK phosphorylation, suggesting that HAT activates ERK through PAR-2 ... Moreover, PAR-2 AP induced AR gene expression subsequent to protein production in the cellular fraction through the ERK pathway indicating that PAR-2 mediated activation of ERK is essential for HAT induced AR production
Syeda et al., J Biol Chem 2006 : PAR-1 and PAR-2 stimulation rapidly activated both ERK1/2 and p38MAPK, and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation
Page et al., Allergy 2006 (Asthma) : We found that selective activation of PAR-2 using the peptide SLIGKV augmented TNFalpha induced MMP-9 protein levels and increased ERK phosphorylation
Jarry et al., Biochem Biophys Res Commun 2007 (Calcium Signaling) : Inhibitors of MAPK activation ( PD98059 ) and EGFR tyrosine kinase activity ( AG1478 ) abrogated PAR-2 induced ERK1/2 and EGFR tyrosine phosphorylation, respectively, and subsequent mucin secretion
van der Merwe et al., Am J Physiol Gastrointest Liver Physiol 2008 (Calcium Signaling) : Immunoblot analysis revealed increases in phosphorylation of epidermal growth factor (EGF) receptor ( EGFR ) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation
Morla et al., J Biol Chem 2008 (Calcium Signaling) : PAR2 activation induced calcium signaling and phosphorylation of ERK1,2
Namkung et al., Am J Physiol Gastrointest Liver Physiol 2008 (Pancreatitis) : Although PAR2 activation by the pretreatment with PAR2 activating peptide ( AP ) itself increased ERK phosphorylation in rat pancreas, the same treatment remarkably decreased caerulein induced activation of ERK and JNK principally by accelerating their dephosphorylation
Tanaka et al., Biochem Biophys Res Commun 2008 : The PAR2 triggered IL-8 release was suppressed by inhibitors of MEK ( U0126 ) or PI3-kinase ( LY294002 ), and PAR2 stimulation indeed activated the downstream kinases, ERK and Akt
van der Merwe et al., Am J Physiol Gastrointest Liver Physiol 2009 : Immunoblots revealed that PAR(2) activation induced phosphorylation of both cRaf and ERK1/2 via PKCdelta
Hasdemir et al., J Biol Chem 2009 : Trapping PAR(2) in endosomes through expression of AMSH ( D348A ) or UBPY ( C786S ) did not prolong the association of PAR(2) with beta-arrestin2 or the duration of PAR(2) induced ERK2 activation ... Thus, AMSH and UBPY are essential for trafficking and down-regulation of PAR(2) but not for regulating PAR(2) dissociation from beta-arrestin2 or PAR(2) mediated ERK2 activation
Lau et al., Am J Physiol Cell Physiol 2011 : Apical PAR2 promoted a rapid, biphasic PLCß/Ca² ( + ) /PKC dependent ERK1/2 activation, resulting in nuclear localization, whereas basolateral PAR2 promoted delayed ERK1/2 activation which was predominantly restricted to the cytosol, involving both PLCß/Ca² ( + ) and ß-arrestin dependent pathways
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012 : Although PAR(2) activation increased ERK MAPK phosphorylation, neither ERK pathway inhibitors nor a p38 MAPK inhibitor affected 2fLI induced COX-2 expression
Zhang et al., Cell Physiol Biochem 2012 (MAP Kinase Signaling System) : Inhibition of PAR-2 suppressed tryptase induced ERK and p38 MAPK pathway activation in microglia
Komatsu et al., J Vet Med Sci 2013 : AH-6809 ( an inhibitor of PGE2 receptors 1 [ EP1 ] and 2 [ EP2 ] ), but not ONO-AE3-208 ( a PGE2 receptor 4 [ EP4 ] inhibitor ), reversed the inhibitory effects of PGE2 on PAR2-AP induced ERK phosphorylation ... Furthermore, forskolin, an adenylate cyclase activator, induced PAR2 internalization and inhibited PAR2-AP induced phosphorylation of ERK
Lin et al., J Biol Chem 2013 : Moreover, thrombin activated PAR1-PAR2 heterodimers enhance ß-arrestin mediated ERK1/2 activation in the cytoplasm, whereas activated ERK1/2 induced by the thrombin activated PAR1 protomer redistributes to the nucleus