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CD4 — PLCG1

Pathways - manually collected, often from reviews:

• Reactome Reaction: CD4 → PLCG1 (reaction) Kim et al., Exp Mol Med 2000

Text-mined interactions from Literome

Wells et al., J Immunol 2003 (Calcium Signaling...) : We demonstrate that primary CD4 ( + ) T cells anergized by costimulatory blockade exhibit impaired TCR coupled phospholipase C (PLC)gamma-1 activation
Kanner et al., Immunology 1992 : Here we show that cross linking of CD4 molecules with CD3 augments the tyrosine phosphorylation of PLC gamma 1, while co-ligation of CD3 with CD45 ( a receptor tyrosine phosphatase ) results in reduced PLC gamma 1 tyrosine phosphorylation