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PIK3R1 — TNFSF10

Text-mined interactions from Literome

Liu et al., Mol Med Report 2010 : Further investigation revealed that TRAIL engagement led to the activation of PI3K/Akt as well as of NF-?B ... Our data demonstrated that the activation of PI3K/Akt and NF-?B by TRAIL is responsible for resistance to TRAIL in human gastric cancer cells
Balzarolo et al., Eur J Immunol 2012 : Furthermore, PI3K signaling is required for NAB2 mediated TRAIL expression
Stagg et al., Am J Surg 2013 : Rat lung microvascular endothelial cells ( RLMECs ) grown on Transwell membranes ( Corning Life Sciences, Lowell, MA ) were treated with recombinant human TRAIL ( 10, 50, and 100 ng/mL ) for 6 hours or TRAIL ( 100 ng/mL ) + LY294002 ( a PI3K inhibitor ; 20 µmol/L ), Z-DEVD-FMK ( a caspase-3 inhibitor ; 10 µmol/L ), or the inhibitors alone