◀ Back to TLR4

TLR4 — TRAF3

Pathways - manually collected, often from reviews:

• Reactome Reaction: TLR4 → TRAF3 (reaction) Fitzgerald et al., Nat Immunol 2003, Mori et al., J Biol Chem 2004, Oganesyan et al., Nature 2006, Häcker et al., Nature 2006, Panne et al., J Biol Chem 2007, Tseng et al., Nat Immunol 2010
• Reactome Reaction: TLR4 → TRAF3 (indirect_complex) Oganesyan et al., Nature 2006, Häcker et al., Nature 2006, Tseng et al., Nat Immunol 2010

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TLR4 — TRAF3 (physical association, affinity chromatography technology) Li et al., Immunity 2011
• IRef Intact Interaction: Complex of STK11IP-TRAF3-TLR4 (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011

Text-mined interactions from Literome

Häcker et al., Nat Rev Immunol 2011 : In this Review, we discuss our current understanding of the role of TRAF3 in TNFR and TLR signalling pathways, and its role in disease
Clark et al., Proc Natl Acad Sci U S A 2011 : Toll-like receptor ( TLR ) ligands that signal via TIR-domain containing adapter inducing IFNß ( TRIF ) activate the I?B kinase ( IKK ) -related kinases, TRAF associated NF?B activator ( TANK) binding kinase-1 (TBK1 ) and IKKe, which then phosphorylate IRF3 and induce the production of IFNß