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POU1F1 — PRKAR1B
Text-mined interactions from Literome
Rajnarayan et al., Mol Endocrinol 1995
:
To directly determine whether
GHF-1 is necessary and
sufficient to mediate the
PKA activation of the rPRL promoter, we established a cotransfection reconstitution assay whereby the activity of an intact and site-specific mutants of the ( -425 to +73 ) rPRL promoter-luciferase reporter gene was reconstituted by cotransfecting expression vectors encoding for either the PKA beta catalytic subunit, GHF-1, or both, into HeLa nonpituitary cells
Caelles et al., Mol Cell Biol 1995
:
As reported here, cAMP agonists and
PKA do not
inhibit GHF-1 activity in living cells and although they stimulate the phosphorylation of GHF-1, the inhibitory phosphoacceptor site within the homeodomain is not affected