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ETS1 — FGF2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Münchberg et al., Mech Dev 1999
:
Expression of the dominant negative FGF receptor mutant in animal caps and embryos blocks XER81 transcription, arguing that the expression of this
Ets gene
requires active
FGF signaling
Tanaka et al., Jpn J Cancer Res 1999
:
bFGF induced the expression of the transcription factor
ETS-1 in MSS31 cells
Iwasaka-Yagi et al., Tohoku J Exp Med 2001
:
When the DNA binding activity of Ets-1 protein was examined,
bFGF was found to
enhance DNA-Ets complex formation, whereas TGF-beta attenuated basal as well as bFGF enhanced DNA-Ets complex formation
Bertrand et al., Cell 2003
:
Ets1/2 mediates general
FGF responsiveness, while the restricted activity of GATAa targets the neural program to the ectoderm
Beh et al., Development 2007
:
In ascidian embryos,
FGF/MAPK mediated
activation of the transcription factor
Ets1/2 is required for heart tissue specification and cell migration
Ekerot et al., Biochem J 2008
:
Negative-feedback regulation of
FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and
mediated by
Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter
Dutta et al., J Biol Chem 2008
(Neovascularization, Pathologic) :
Mechanistic analyses revealed that in endothelial cells
EGF/FGF2 signaling
induces ETS1 expression, increases HIF-2alpha protein level in absence of hypoxia, and recruits both ETS1 and HIF-2alpha to the VEGFR1 chromatin domain
Mao et al., Dev Cell 2009
(Polydactyly) :
Here, we show that
FGF dependent activation of the
ETS transcription factors Etv4 and Etv5 contributes to proximal-distal limb outgrowth
Li et al., Pharm Biol 2010
(Carcinoma...) :
The
effects of
bFGF on
Ets-1 expression and the invasion ability of SKOV ( 3 ) cells were determined both before and after exposure to different concentrations of bFGF for 24 h ...
bFGF can enhance the invasion ability of ovarian cancer cells in vitro by inducing the expression of uPA, and this effect is also
regulated by the transcription factor
Ets-1
Woznica et al., Dev Biol 2012
:
The Ciona heart progenitor lineage is first specified by Fibroblast Growth Factor/Map Kinase (
FGF/MapK )
activation of the transcription factor
Ets1/2 ( Ets )
Samakovlis et al., Development 1996
:
We further show that the breathless
FGF receptor, a tracheal gene required for primary branching, is also required to activate expression of markers involved in secondary branching and that the pointed
ETS-domain transcription factor is
required for secondary branching and also to activate expression of terminal branch markers
Schweppe et al., J Biol Chem 1997
:
However, overexpression of
Ets-1 and GHF-1, which potentiate the Ras response,
inhibits FGF stimulation of the rPRL promoter, implying that Ras and FGF signaling pathways target distinct factors to elicit their effects