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ANGPT2 — PLA2G4A

Text-mined interactions from Literome

Parmentier et al., Hypertension 2001 : These data suggest that the CYP4A metabolite 20-HETE, which is generated from arachidonic acid after cPLA(2) activation by Ang II , stimulates the ras/MAP kinase pathway, which in turn activates PLD2 and releases further arachidonic acid for prostaglandin synthesis through the phosphatidate phosphohydrolase/diacylglycerol lipase pathway
Silfani et al., Arch Biochem Biophys 2002 : Also, using Western analysis, Ang II increased the phosphorylation of MAPK and cPLA(2) which were blocked by the MAPK kinase inhibitor PD98059 ( 10 microM/L )
Li et al., J Pharmacol Exp Ther 2005 : Furthermore, ETYA, cPLA(2) antisense, and cPLA(2) siRNA attenuated Ang II-elicited PLD activation ... These data indicate that Ang II-stimulated Akt activity is mediated by cPLA(2) dependent, p38 MAPK regulated PLD(2) activation and EGFR transactivation