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EPHB2 — NEUROD6
Text-mined interactions from Literome
Ghil et al., J Neurochem 2000
:
Thus, activation of
Erk may not be
essential for
neuronal differentiation in F11 cells and alphao may cause changes in NOG by inhibiting CREB activation
Olsson et al., Exp Cell Res 2000
(Neuroblastoma) :
However, activation and nuclear accumulation of
ERK were not
sufficient to induce
neuronal differentiation in SH-SY5Y, as demonstrated by the response to TPA in serum-free cultures
Harada et al., Nat Cell Biol 2001
:
In PC12 cells, sustained activation of
ERK induced by nerve-growth factor (NGF) is
essential for
neuronal differentiation
Hansen et al., Neurosci Lett 2003
:
The results demonstrate that PKA and
ERK play a key role in KCl- and forskolin induced
neuronal differentiation by integration of signals from both pathways
Hetman et al., Eur J Biochem 2004
(MAP Kinase Signaling System) :
In the nervous system,
ERK1/2 is
critical for
neuronal differentiation , plasticity and may also modulate neuronal survival
Lee et al., J Neurochem 2004
(Neuroblastoma) :
Our results suggest that
ERK1/2 and PKA induced regulation of Cdk5 activity possibly through Egr-1, c-fos, and CREB
plays a critical role in the RA-induced
neuronal differentiation
Katakowski et al., Neurosci Lett 2005
:
EphB2 transiently down-regulated SVZ cell mRNA of Notch1 and Zic1, genes that
regulate neurogenesis and
neuronal differentiation
Kim et al., Toxicology 2007
(Neuroblastoma) :
Thus, it indicates that the
neuronal differentiation with RA was
mediated by the
ERK1/2 and PKC related pathway and MeHg resulted in neurotoxic influences through the disturbance in steps of differentiation by this pathway
Rudolph et al., Biochim Biophys Acta 2007
(MAP Kinase Signaling System) :
Rit mutants confirm
role of
MEK/ERK signaling in
neuronal differentiation and reveal novel Par6 interaction
Yang et al., J Biol Chem 2008
(MAP Kinase Signaling System) :
Basic fibroblast growth factor induced
neuronal differentiation of mouse bone marrow stromal cells
requires FGFR-1,
MAPK/ERK , and transcription factor AP-1
Wang et al., Neurosci Lett 2009
:
We also found that nerve growth factor (NGF) and collagen could promote the proliferation and
inhibit neuronal differentiation by activating phosphorylation of
Erk1/2
Washio et al., Exp Cell Res 2009
:
Our findings indicate that HA
inhibits NGF induced
neuronal differentiation of PC12 cells partially by inhibiting
ERK phosphorylation through RHAMM, and suggest that the binding of HA to RHAMM modifies the signaling pathways in PC12 cells treated with NGF
Marcucci et al., J Biol Chem 2010
:
Both PtdCho biosynthesis and
neuronal differentiation are
dependent on
ERK activation
Pan et al., J Biol Chem 2012
:
Moreover, neurotrophins including NT3 activate ERK5 and stimulate
neuronal differentiation in aNPCs in an
ERK5 dependent manner
Lonic et al., J Biol Chem 2013
(MAP Kinase Signaling System) :
The regulation of Ras and
ERK signaling by Ser ( 779 ) was
critical not only for
neuronal differentiation but also for cell survival under limiting growth factor concentrations
Li et al., Toxicological sciences : an official journal of the Society of Toxicology 2013
:
Furthermore, inhibition of
ERK5 signaling may
underlie the adverse effect of 6-OH-PBDE-47 on proliferation and
neuronal differentiation
Yao et al., J Biol Chem 1998
:
Induction of
neuronal differentiation of the rat pheochromocytoma cell line, PC12 cells, by nerve growth factor (NGF)
requires activation of the mitogen activated protein ( MAP ) kinase or extracellular signal regulated kinase (
ERK )