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EPHB2 — XRCC5
Text-mined interactions from Literome
Mochizuki et al., Nature 1999
:
This decrease in GTP bound
Rap1 activates
ERK/MAPK
Pizon et al., Oncogene 2000
(MAP Kinase Signaling System) :
We provide evidence that
Rap1A mutants
promote ERK activation and that the active protein induces a more sustained activation than the inactive protein
Sawada et al., J Cell Sci 2001
(MAP Kinase Signaling System) :
Rap1 is
involved in cell stretching modulation of p38 but not
ERK or JNK MAP kinase ... Furthermore, overexpression of
Rap1 enhanced p38 activity but not
ERK or JNK activity
Garcia et al., Mol Cell Biol 2001
:
We show that the small GTPases Ras and
Rap1 contribute together to TPO induced
ERK activation in UT7-Mpl cells and that they do so by activating different Raf kinases as downstream effectors : a Ras-Raf-1 pathway is required to initiate ERK activation while Rap1 sustains this signal through B-Raf ... Indeed, ( i ) in cells expressing wild-type or mutant Mpl, TPO induced Ras and Rap1 activation correlates with early and sustained phases of ERK signal, respectively ; ( ii ) interfering mutants of Ras and
Rap1 both
inhibit ERK kinase activity and ERK dependent Elk1 transcriptional activation in response to TPO ; ( iii ) the kinetics of activation of Raf-1 and B-Raf by TPO follow those of Ras and Rap1, respectively ; ( iv ) RasV12 mediated Elk1 activation was modulated by the wild type or interfering mutants of Raf-1 but not those of B-Raf ; ( v ) Elk1 activation mediated by a constitutively active mutant of Rap1 ( Rap1V12 ) is potentiated by B-Raf and inhibited by an interfering mutant of this kinase
Schmitt et al., Mol Cell Biol 2001
:
In NIH 3T3 cells,
Rap1 is
required not only for cAMP 's inhibition of
ERK activation but for inhibition of cell proliferation and mitogenesis as well
Wang et al., J Biol Chem 2001
:
Moreover, inhibition of
Rap1 by a Rap1 GTPase activating protein-1 also
resulted in a decrease in
ERK and Akt phosphorylation, which was not further decreased by cAMP, suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 ... The
role of
Rap1 in
ERK and Akt activity was further demonstrated by our observation that an active form of Epac, which activated Rap1 in the absence of cAMP, increased ERK and Akt phosphorylation
Iacovelli et al., Mol Pharmacol 2001
:
The Rap1 dominant negative
Rap1N17 significantly
reduced TSH stimulated but not insulin-like growth factor 1-stimulated
ERK1/2 phosphorylation, whereas the Ras dominant negative RasN17 inhibited the effect of both agonists
Fujita et al., J Biol Chem 2002
:
cAMP stimulated Ras independent and
Rap1 dependent
ERK phosphorylation and cell proliferation in B-Raf expressing cells, but inhibited growth in B-Raf lacking cells
Grader-Beck et al., Blood 2003
:
Thus, TCR plus CD28 mediated activation of
ERK1/2 and PKB, cytokine production, and cell cycle progression, all of which are inhibited by cAMP,
require activation of Ras but not
Rap1
Enserink et al., Nat Cell Biol 2002
:
We conclude that cAMP induced regulation of
ERK and
activation of
Rap1 are independent processes
Schulte et al., Exp Cell Res 2003
:
Inhibition of phosphatidylinositol-3'-kinase (PI3K) by wortmannin inhibited adenosine A(2B) receptor mediated
ERK1/2 phosphorylation and
activation of
Rap1 , without affecting CREB and p38 phosphorylation
Romano et al., J Biol Chem 2003
:
Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38, whereas
Rap1 is poorly
involved in TRH or EGF induced
ERK activation
Arévalo et al., EMBO J 2004
:
ARMS is rapidly tyrosine phosphorylated after binding of neurotrophins to Trk receptors and provides a docking site for the CrkL-C3G complex, resulting in
Rap1 dependent sustained
ERK activation
Calipel et al., J Biol Chem 2006
(Cell Transformation, Neoplastic...) :
This ruled out a
role for
Rap1 in the PKA mediated
B-Raf/ERK activation in ( WT ) B-Raf cells
Wang et al., Mol Cell Biol 2006
:
We confirm that the PKA independent activation of
Rap1 by Epac1 activates a perinuclear pool of Rap1 and that this does not
result in
ERK activation
Wang et al., J Biol Chem 2006
:
Our data indicate that activation of Rap1 or MEKK2 is sufficient to stimulate ERK5, whereas inhibition of either
Rap1 or MEKK2
attenuates BDNF activation of
ERK5
Kogut et al., Mol Immunol 2007
:
Rap1 has been shown to
activate the
ERK1/2 via a different Raf family member B-Raf whose downstream effector is MEK1/2
Xie et al., Mol Pharmacol 2007
(MAP Kinase Signaling System...) :
Furthermore, PKA dependent
Rap1 activation is
required for both
ERK1/2 activation and androgen independent AR activation in LNCaP cells upon VIP stimulation
Wakamatsu et al., J Biol Chem 2007
:
Moreover, Ca2+ induced
activation of
ERK through
Rap1 and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes ; in turn, the inhibition of ERK activation reduced the amount of loricrin in wild-type keratinocytes
Pertuit et al., Endocrinology 2011
:
In this study on the conditional gsp-oncogene expressing GH4C1 cell line, expression of the gsp oncogene, which was observed in up to 40 % of GH-secreting adenomas, was found to induce sustained
ERK1/2 activation, which
required activation of the protein kinase A and the GTPases Ras and
Rap1