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ESR1 — IGF2
Text-mined interactions from Literome
Klotz et al., Endocrinology 2000
:
The dose of chemical necessary to activate IGF-I signaling varied, with the order of potency : E2 = diethylstilbestrol > LY353381 > 4-hydroxytamoxifen > genistein > HPTE > bisphenol A. Administration of the chemicals to ERalpha knockout mice did not activate IGF-IR, indicating that
ERalpha is
required for activation of uterine
IGF-IR by these diverse chemicals
Oesterreich et al., Cancer Res 2001
(Breast Neoplasms) :
To prove that loss of
IGF and estrogen mediated signaling and growth was a
consequence of loss of
ERalpha , we re-expressed ERalpha in C4-12 cells by stable transfection with HA-tagged ERalpha
Surmacz et al., J Exp Clin Cancer Res 2004
(Breast Neoplasms) :
Most notably, activation of
ERalpha upregulates the expression of IRS-1,
IGF-IR , and IGF-1, which results in amplification of IGF-I responses ... Reciprocally, stimulation of
IGF-IR increases the phosphorylation and activity of
ERalpha
Reizner et al., J Mol Endocrinol 2005
(Breast Neoplasms) :
Triple cotransfection experiments using an ERalpha expression vector in the absence or presence of WT1 expression vectors, along with an IGF-IR promoter reporter plasmid, revealed that
ERalpha stimulated
IGF-IR promoter activity whereas coexpression of WT1 abrogated the effect of ERalpha
Garcia-Segura et al., Neuroendocrinology 2006
:
Conversely,
IGF-I regulates
ERalpha transcriptional activity in neuroblastoma cells and the PI3K/Akt/GSK3 signaling pathway is involved in this effect
Maor et al., J Endocrinol 2006
(Breast Neoplasms) :
The aim of our study was to examine the transcriptional mechanisms involved in
regulation of
IGF-IR gene expression by the
estrogen receptor ( ER ) ... In summary, our studies demonstrate that
IGF-IR gene transcription in breast cancer cells is
controlled by interactions between
ERalpha and Sp1
Sunters et al., J Biol Chem 2010
:
Strain related
IGF-IR activation of AKT
requires estrogen receptor alpha (ERalpha) with which IGF-1R physically associates
Lee et al., Biomed Pharmacother 1995
(Breast Neoplasms) :
In addition, recent data now indicate that
IGF ligands can also
activate estrogen receptor ( ER ) in a ligand independent manner