Gene interactions and pathways from curated databases and text-mining

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CISH — IRF6

Text-mined interactions from Literome

Crespo et al., Eur J Immunol 2002 (MAP Kinase Signaling System) : These observations are mechanistically consistent with the known induction of suppressors of cytokine signaling (SOCS)-1 and SOCS-3 proteins by LPS
Kinjyo et al., Immunity 2002 : We show here that the suppressor of cytokine-signaling-1 ( SOCS1/JAB ) is rapidly induced by LPS and negatively regulates LPS signaling
Tassiulas et al., Hum Immunol 2007 (MAP Kinase Signaling System) : Apoptotic cells had minimal effects on LPS induced activation of NF-kappaB and MAPKs, but induced expression of SOCS proteins and substantially suppressed induction of CXCL10 expression by IFN-alpha
Hu et al., J Immunol 2009 (Cryptosporidiosis...) : Using in vitro models using normal human biliary epithelial cells ( cholangiocytes ), we demonstrated that LPS stimulation or infection with the parasitic protozoan Cryptosporidium parvum induced expression of CIS protein without a change in CIS mRNA levels by activating the TLR signaling pathway
Wang et al., Fish Shellfish Immunol 2010 (Fish Diseases...) : However, PMA stimulation did impact on SOCS6 and SOCS9 expression, and LPS stimulation of primary cultures or bacterial infection ( Yersinia ruckeri ) increased significantly CISH expression ( as well as SOCS1 and SOCS2 or SOCS3 respectively )
Ban et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011 : Interestingly, among genes related to macrophage mediated immunity, LPS increased the expression of seven genes ( Adora2b, Fcgr2b, Cish , Cxcl10, Clec4n, Il1a, and Il1b ) and decreased the expression of one gene ( Clec4a3 )
Kerr et al., Neuroscience 2012 : URB597 attenuated the LPS induced increase in interleukin (IL)-1ß expression while concurrently augmenting the LPS induced increase in suppressor of cytokine signalling (SOCS)-3 expression
Yang et al., Exp Physiol 2012 (Asthma...) : Parallel to the alteration of degranulation, LPS increased FceRI activated Ca ( 2+ ) mobilization, as well as Ca ( 2+ ) entry through store operated calcium channels (SOCs) evoked by thapsigargin
Minogue et al., Journal of neuroinflammation 2012 (MAP Kinase Signaling System) : Co-treatment of glia with LPS and recombinant IL-6 protein attenuated the LPS induced release of both TNF a and IL-1 ß while potentiating the effect of LPS on suppressor of cytokine signaling (SOCS)3 expression and IL-10 release
Kim et al., J Clin Invest 2013 (Lupus Erythematosus, Systemic) : Let-7c reciprocally inhibited Blimp1 and also blocked LPS induced suppressor of cytokine signaling-1 ( SOCS1 ) expression, contributing to the proinflammatory phenotype of Blimp1-deficient DCs