◀ Back to CSF2
CSF2 — SHC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database GMCSF-mediated signaling events:
None
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA)
(modification, collaborate)
Ramshaw et al., Blood 2007
Evidence: mutant phenotype
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA)
→
None
(modification, activates)
Ramshaw et al., Blood 2007
Evidence: mutant phenotype
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA)
(modification, collaborate)
Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
SHC (SHC1)
(modification, collaborate)
Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA)
→
SHC (SHC1)
(modification, collaborate)
Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
(modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA)
(modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
None
(modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
None
(modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
-
NCI Pathway Database GMCSF-mediated signaling events:
GRB2/GAB2 complex (GRB2-GAB2)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA)
→
SHC (SHC1)
(modification, collaborate)
Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA)
(modification, collaborate)
Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
SHC (SHC1)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA)
(modification, collaborate)
Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA)
(modification, collaborate)
Ramshaw et al., Blood 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
SHIP (INPP5D)
(modification, collaborate)
Ramshaw et al., Blood 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA)
→
SHIP (INPP5D)
(modification, collaborate)
Ramshaw et al., Blood 2007
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
CSF2
→
SHC1
(indirect_complex)
-
Reactome Reaction:
CSF2
→
SHC1
(reaction)
Gu et al., Mol Cell Biol 2000, Pratt et al., J Biol Chem 1996
Text-mined interactions from Literome
Okuda et al., Ann N Y Acad Sci 1999
:
Tyrosine 577 was found to be sufficient to regenerate
GM-CSF dependent phosphorylation of
SHC , and any of Y577, Y612, or Y695 were sufficient to regenerate GM-CSF-inducible phosphorylation of SHP2
Matsuguchi et al., J Biol Chem 1994
(Leukemia, Megakaryoblastic, Acute) :
Shc phosphorylation in myeloid cells is
regulated by granulocyte macrophage
colony stimulating factor , interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL
Dorsch et al., Biochem Biophys Res Commun 1994
:
Tyrosine phosphorylation of
Shc is
induced by IL-3, IL-5 and
GM-CSF
Pratt et al., J Biol Chem 1996
:
These observations provide an explanation for the previously described requirement for Tyr577 of beta c for
GM-CSF induced tyrosine phosphorylation of
Shc and have implications for Ras activation through the GM-CSF, IL-3, and IL-5 receptors
Watanabe et al., J Biol Chem 1996
:
Further analyses of the role of JAK2 in c-fos gene activation in BA/F3 cells expressing hGMR revealed that delta JAK2 inhibited
hGM-CSF induced phosphorylation of
Shc and protein tyrosine phosphatase 1D
Durstin et al., J Immunol 1996
:
in the present study, we show that Y577 is required for phosphorylation of
Shc and an Shc associated p140 in
response to
GM-CSF ... These data indicate that the phosphorylation of
Shc in
response to
GM-CSF is not required for proliferation or viability signaling in these cells
Shi et al., Biochem Mol Biol Int 1996
(Leukemia, Erythroblastic, Acute) :
This report demonstrates that
GM-CSF induces the tyrosine phosphorylation of
Shc protein which is implicated in Ras activation
Okuda et al., Blood 1997
:
However,
GM-CSF induced tyrosine phosphorylation of both SHP2 and
SHC was reduced or absent compared with wild-type ... Tyrosine 577 was found to be sufficient to regenerate
GM-CSF dependent phosphorylation of
SHC , and any of Y577, Y612, or Y695 was sufficient to regenerate GM-CSF-inducible phosphorylation of SHP2
Ooi et al., Biochem Biophys Res Commun 1998
(Leukemia, Erythroblastic, Acute) :
While
GM-CSF caused association of Stat5 and
Shc with beta c, TPO caused association of Stat5, but not Shc, with beta c, suggesting that TPO and GM-CSF may not induce phosphorylation of the same sets of tyrosine residues in beta c
Ward et al., Biochim Biophys Acta 1998
:
In this report, we show rapid phosphorylation of Shc upon
stimulation of NFS-60 cells with
G-CSF , and inducible association of
Shc and Grb2 with the G-CSF-R in these cells