Gene interactions and pathways from curated databases and text-mining

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CSF2 — SHC1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Okuda et al., Ann N Y Acad Sci 1999 : Tyrosine 577 was found to be sufficient to regenerate GM-CSF dependent phosphorylation of SHC , and any of Y577, Y612, or Y695 were sufficient to regenerate GM-CSF-inducible phosphorylation of SHP2
Matsuguchi et al., J Biol Chem 1994 (Leukemia, Megakaryoblastic, Acute) : Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony stimulating factor , interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL
Dorsch et al., Biochem Biophys Res Commun 1994 : Tyrosine phosphorylation of Shc is induced by IL-3, IL-5 and GM-CSF
Pratt et al., J Biol Chem 1996 : These observations provide an explanation for the previously described requirement for Tyr577 of beta c for GM-CSF induced tyrosine phosphorylation of Shc and have implications for Ras activation through the GM-CSF, IL-3, and IL-5 receptors
Watanabe et al., J Biol Chem 1996 : Further analyses of the role of JAK2 in c-fos gene activation in BA/F3 cells expressing hGMR revealed that delta JAK2 inhibited hGM-CSF induced phosphorylation of Shc and protein tyrosine phosphatase 1D
Durstin et al., J Immunol 1996 : in the present study, we show that Y577 is required for phosphorylation of Shc and an Shc associated p140 in response to GM-CSF ... These data indicate that the phosphorylation of Shc in response to GM-CSF is not required for proliferation or viability signaling in these cells
Shi et al., Biochem Mol Biol Int 1996 (Leukemia, Erythroblastic, Acute) : This report demonstrates that GM-CSF induces the tyrosine phosphorylation of Shc protein which is implicated in Ras activation
Okuda et al., Blood 1997 : However, GM-CSF induced tyrosine phosphorylation of both SHP2 and SHC was reduced or absent compared with wild-type ... Tyrosine 577 was found to be sufficient to regenerate GM-CSF dependent phosphorylation of SHC , and any of Y577, Y612, or Y695 was sufficient to regenerate GM-CSF-inducible phosphorylation of SHP2
Ooi et al., Biochem Biophys Res Commun 1998 (Leukemia, Erythroblastic, Acute) : While GM-CSF caused association of Stat5 and Shc with beta c, TPO caused association of Stat5, but not Shc, with beta c, suggesting that TPO and GM-CSF may not induce phosphorylation of the same sets of tyrosine residues in beta c
Ward et al., Biochim Biophys Acta 1998 : In this report, we show rapid phosphorylation of Shc upon stimulation of NFS-60 cells with G-CSF , and inducible association of Shc and Grb2 with the G-CSF-R in these cells