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RAC1 — RAC3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Aspenström et al., Biochem J 2004
:
Cdc42, TCL ( TC10-like ),
Rac1-Rac3 and RhoG
induced the formation of lamellipodia, whereas Cdc42,
Rac1 and Rac2 also induced the formation of thick bundles of actin filaments
Pan et al., Zhonghua Zhong Liu Za Zhi 2003
(Gastrointestinal Neoplasms) :
The increased mRNA expression of Rac1 and
Rac3 in gastrointestinal cancer cell lines and the abnormal
activation of
Rac1 protein in gastric cancer cell lines might be correlated with the carcinogenesis of gastrointestinal cancer
Sánchez-Martín et al., J Biol Chem 2004
:
We have identified Vav, a guanine nucleotide exchange factor for Rac-1, and PI3K/Akt, as regulators of the activation and inactivation phases of the activity of Rac-1, respectively, in the context of LFA-1 signaling based on the following experimental evidence : ( i ) LFA-1 induced activation of Vav and PI3K/Akt with kinetics consistent with a regulatory role for these molecules on
Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces
activation of
Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation, ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity, and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited, respectively, Rac-1 activity
Shyu et al., J Biomed Sci 2009
:
TNF-alpha induced phosphorylation of Rac, while atorvastatin and
Rac-1 inhibitor
inhibited the phosphorylation of
Rac induced by TNF-alpha