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APEX1 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: APEX1 — TP53 Seemann et al., Oncogene 2005*
• IRef Bind_translation Interaction: APEX1 — TP53 (coimmunoprecipitation) Seemann et al., Oncogene 2005*
• IRef Biogrid Interaction: APEX1 — TP53 (association, biochemical) Jayaraman et al., Genes Dev 1997*
• IRef Biogrid Interaction: APEX1 — TP53 (physical association, affinity chromatography technology) Seemann et al., Oncogene 2005*
• IRef Hprd Interaction: APEX1 — TP53 (in vivo) Jayaraman et al., Genes Dev 1997*
• IRef Ophid Interaction: APEX1 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: APEX1 — TP53 (aggregation, confirmational text mining) Jayaraman et al., Genes Dev 1997*

Text-mined interactions from Literome

Ueno et al., J Biol Chem 1999 (Colonic Neoplasms) : Luciferase assay revealed that transfection of TRX enhanced p53 dependent expression of p21 and further intensified Ref-1 mediated p53 activation
Robertson et al., Cancer Res 2001 (Carcinoma, Embryonal...) : Moreover, Ape1/ref-1 stimulates the DNA binding activity of transcription factors ( Fos-Jun, nuclear factor-kappaB, Myb, ATF/cyclic AMP-responsive element binding protein family, HIF-1alpha, HLF, PAX, and p53 ) through a redox mechanism and thus represents a novel component of signal transduction processes that regulate eukaryotic gene expression
Hanson et al., Oncogene 2005 : Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization ... Whereas stimulation of p53 DNA binding by the redox activities of Ref-1 is understood quite well, little is known about mechanisms that underlie the redox independent effects of Ref-1
Seemann et al., Oncogene 2005 (Breast Neoplasms) : Roles of thioredoxin reductase 1 and APE/Ref-1 in the control of basal p53 stability and activity ... To evaluate the role of TRR and APE/Ref-1 in p53 regulation, we have abrogated their expression using RNA interference in cell lines expressing wild-type p53 ... However, inhibition of either TRR or APE/Ref-1 did not prevent activation and accumulation of p53 in response to DNA-damage by doxorubicin
Gurusamy et al., Antioxid Redox Signal 2009 : Further, inhibition of Ref-1 increased the level of p53 but decreased the phosphorylation of Akt, a molecule involved in survival signaling
Unnikrishnan et al., Free Radic Biol Med 2009 : In addition, loss of APE1/Ref-1 increases the apoptotic response to oxidative stress, in which significant increases in GADD45g expression, p53 protein stability, and caspase activity are observed
Bhattacharyya et al., Gastroenterology 2009 (Helicobacter Infections) : Apurinic/apyrimidinic endonuclease-1 ( APE-1 ) regulates transcriptional activity of p53 , and H pylori induce APE-1 expression in human GECs
Pei et al., Mutat Res 2013 : In addition, Apex1 indirectly regulates levels of p53
Jayaraman et al., Genes Dev 1997 : Importantly, we have also determined that Ref-1 can stimulate p53 transactivation in vivo