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IGF1 — TP53
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IGF1
→
TP53
(decreases, TP53 Activity)
Evidence: IGFbPs limit IGF access to IGF1R, thereby attenuating the bioactivity of these growth factors33. The tumour suppressor p53 (REF. 34), as well as many growth inhibitors including vitamin d35, anti- oestrogens36, retinoids37, and transforming growth factor-? (TGF?37), reduce IGF bioactivity by increasing the secretion of IGFbPs33.
Text-mined interactions from Literome
Girnita et al., Cancer Res 2000
(Melanoma) :
Taken together, our results suggest that up-regulation of
IGF-IR as a
result of expression of aberrant
p53 may be important for the growth and survival of malignant cells
Idelman et al., J Biol Chem 2003
(Bone Neoplasms...) :
WT1 splice variants lacking a KTS insert between zinc fingers 3 and 4 suppressed
IGF-IR promoter activity in the absence of p53 or in the
presence of wild-type
p53 ... In the
presence of mutant
p53 , WT1 can not repress the
IGF-IR promoter
Lee et al., Mol Cell Endocrinol 2003
(Carcinoma, Hepatocellular) :
p53mt249 increased the number of IGF-II binding sites with no change in the affinity of
IGF-IR
Harms et al., Mol Cell Biol 2005
:
Through the use of engineered deletion mutants, we found that activation domain 2 is required for
induction of the proapoptotic target gene
insulin-like growth factor binding protein 3 ( IGFBP3 ) by
p53 and that the basic domain inhibits induction of this gene by p53
Clark et al., Int J Cancer 2005
(Breast Neoplasms) :
Although
IGF-I acutely
suppressed the
p53 response to both agents, it subsequently enhanced the chronic increase in p53 and p21 ( WAF1/Cip1 ), resulting in cell cycle arrest ; however, no apoptosis was observed
Ma et al., J Exp Clin Cancer Res 2006
(Adenocarcinoma...) :
It was also found that the absence of mutant
p53 affected the signal transduction of TGFbeta/BMP pathway mainly by up-regulating the expression of BMP superfamily cytokine growth differentiation factor 9 (GDF9), activin superfamily cytokine inhibin beta B (INHBB), smads target genes
insulin-like growth factor binding protein 3 ( IGFBP3 ) and involucrin (IVL)
Adamson et al., Altern Lab Anim 2007
:
Under these conditions,
IGF-1 may
increase p53 expression to restrain abnormal cell proliferation
Bocchetta et al., Cancer Res 2008
(Cell Transformation, Neoplastic) :
The SV40 large T
antigen-p53 complexes bind and
activate the
insulin-like growth factor-I promoter stimulating cell growth ... We found that in human cells,
Tag-p53 complexes
regulate transcription of the
insulin-like growth factor I (IGF-I) gene by binding to the IGF-I promoter together with pRb and p300
Scrable et al., Exp Gerontol 2009
(Starvation) :
Running on empty : how
p53 controls
INS/IGF signaling and affects life span
Li et al., Rejuvenation Res 2008
(Calcium Signaling...) :
Our data suggest that regulation of Akt,
p53 , adenosine monophosphate activated protein kinase ( AMPK ) phosphorylation, and Klotho may
play a role, at least in part, in
IGF-1 deficiency induced `` desensitization '' of cardiac aging
Kuramoto et al., Acta Med Okayama 2008
(Cervical Intraepithelial Neoplasia...) :
It is postulated that a decrease of
p53 protein levels due to human papillomavirus ( HPV ) infection may
contribute to the up-regulation of
IGF-IR expression in cervical cancer cells because transcription of IGF-IR is strictly down-regulated by p53
Goetz et al., Oncogene 2011
(Genomic Instability...) :
Here, we show that activation of Ataxia telangiectasia mutated kinase ( ATM ) by endogenous or exogenous forms of DNA damage was required to relieve basal
repression of
IGF-1 transcription by the
p53/NF-YA complex, leading to sCLU expression
Attias-Geva et al., Eur J Cancer 2012
(Cystadenocarcinoma, Serous...) :
In addition, using USC derived cell lines we provide evidence that
p53 regulates
IGF-IR gene expression via a mechanism that involves repression of the IGF-IR promoter ... In summary, we provide evidence that
p53 regulates
IGF-IR gene expression in USC cells via a mechanism that involves repression of the IGF-IR promoter
Chen et al., Endocrinology 1995
:
In order to understand the mechanisms through which IGF I regulates cardiac muscle growth, we have studied the
effects of
IGF I on inhibitory pathways involving
p53 and WAF1 in cultured cardiac muscle cell line H9C2
Werner et al., Proc Natl Acad Sci U S A 1996
:
On the other hand, three tumor derived mutant forms of
p53 ( mut 143, mut 248, and mut 273 )
stimulated the activity of the
IGF-I-R promoter and increased the levels of IGF-I-R/luciferase fusion mRNA
Ohlsson et al., Endocrinology 1998
(Osteosarcoma) :
p53 regulates
insulin-like growth factor-I (IGF-I) receptor expression and IGF-I induced tyrosine phosphorylation in an osteosarcoma cell line : interaction between p53 and Sp1 ... The aim of the present study was to investigate whether the
IGF-IR is a physiological
target for
p53 in osteosarcoma cells ... The
p53 induced regulation of
IGF-IR levels was studied in a tetracycline regulated expression system ... When expressed in Saos-2, osteosarcoma cells that lack p53, wild-type p53 decreased, whereas mutated
p53 increased
IGF-IR expression, and IGF-I induced tyrosine phosphorylation of the IGF-IR ... However, Sp1 counteracted the inhibitory
effect of
p53 on
IGF-IR promoter activity in a dose dependent manner ... In conclusion,
p53 regulates
IGF-IR expression, as reflected by a reduction in IGF-IR protein and a parallel reduction in IGF-I induced tyrosine phosphorylation of the IGF-IR and IRS-1 in an osteosarcoma cell line
Cianfarani et al., Eur J Clin Invest 1998
(Chromosome Fragility) :
In vitro
effects of growth hormone (GH) and
insulin-like growth factor I and II ( IGF-I and -II ) on chromosome fragility and
p53 protein expression in human lymphocytes ...
IGF-I and -II also
stimulate p53 protein expression that, taking part in DNA repair, may counteract the IGF action on genome stability
Wang et al., Biochem Biophys Res Commun 1998
:
IGF I induction of
p53 requires activation of MAP kinase in cardiac muscle cells ... The aim of this study was to investigate whether
IGF I induction of
p53 expression and p21 promoter require activation of MAP kinase in cardiac muscle cells ... These data indicate that transcriptional
activation of
p53 and p21WAF1/CIP1 by
IGF I involves MAP kinase pathway in cardiomyocytes, and thus link MAP kinase to negative modulation of the cell cycle in cardiac muscle cells