Carbone et al., Oncogene 2002
:
PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage
Kool et al., Oncogene 2003
(MAP Kinase Signaling System) :
Using specific inhibitors, we found that the ATM- and Nibrin1 dependent activation of ATF3 does neither require p53 nor reactive oxygen species, but is dependent on the p38 and JNK MAPkinases
Rogoff et al., Mol Cell Biol 2004
:
Both Atm and Nbs1 contribute to Chk2 activation and p53 phosphorylation following deregulation of normal Rb growth control
Song et al., Nat Cell Biol 2007
(Cell Transformation, Neoplastic...) :
These acquired oncogenic properties of mutant p53 could be explained by the findings that these p53 mutants interact with the nuclease Mre11 and suppress the binding of the Mre11-Rad50-NBS1 (MRN) complex to DNA double stranded breaks ( DSBs ), leading to impaired Ataxia-telangiectasia mutated (ATM) activation
Peche et al., Cell Death Differ 2012
:
These results correlate with a reduction in NBs number and an impaired p53 response