◀ Back to TP53
SYT1 — TP53
Text-mined interactions from Literome
Gu et al., Blood 2002
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
In the
presence of wild-type ( wt )
p53 , MDM2 increased
p65 promoter activity by reversing p53 mediated suppression of p65
Ryan et al., Cancer Res 2004
:
Here, we show that loss of
p65 , a critical subunit of NF-kappaB, can
cause resistance to different agents that signal death through
p53
Jeong et al., J Biol Chem 2005
:
A novel NF-kappaB pathway
involving IKKbeta and
p65/RelA Ser-536 phosphorylation results in
p53 Inhibition in the absence of NF-kappaB transcriptional activity
Rajakangas et al., Int J Cancer 2006
(Adenoma...) :
The results suggest that
p65 is involved in a
p53 dependent apoptotic response in the Min mouse
Dhar et al., J Biol Chem 2010
:
Expression of
p53 enhances nuclear levels of
p65 with corresponding increase in the DNA binding activity of NF-kappaB as detected by electrophoretic mobility shift and chromatin immunoprecipitation assays
Park et al., Mol Carcinog 2012
(Colonic Neoplasms...) :
HFD feeding increased tumor tissue levels of Ki67, cyclin A, cyclin D1, CDK2, Bcl-xL, and Bcl-2 ; reduced
p53 levels and TUNEL positive apoptotic cells ; increased the levels of CD45, CD68, CD31, VEGF, P-VEGF receptor-2, iNOS, and COX-2 as well as hemoglobin content ; and
increased the levels of HIF-1a, P-STAT3-Y705, P-STAT3-S727, P-I?B-a,
P-p65 , p65, P-c-Jun, P-Akt, P-ERK1/2, P-p38, and P-SAPK/JNK
Suzuki et al., PloS one 2011
:
p53 inhibits not only the catalytic activity of IKK2 presumably through the modulation of glycosylation but also
p65 ( RelA ) -mediated transactivation
Li et al., BMC molecular biology 2012
(Esophageal Neoplasms) :
In addition, we found that overexpression of NF-kappaB
p65 could not successfully
induce miR-34a expression in esophageal cancer cell lines with mutant
p53 or decreased p53
Lin et al., PloS one 2012
:
ER stress induced
p53 expression was significantly
inhibited by coincubation with the NF-?B inhibitor, Bay 11-7082 and downregulation of NF-?B
p65 expression
Sun et al., Mol Cell Biol 1995
:
Although a kappa B motif partially overlaps with this element and those genotoxic agents activate NF-kappa B, it does not play a major role in p53 genotoxic stress response : NF-kappa B
p65 expression did not induce significant p53 promoter activation, and NF-kappa B inhibitors ( N-acetyl cysteine and I kappa B alpha ) did not
inhibit genotoxic stress-inducible
p53 promoter activation
Wu et al., J Biol Chem 1994
:
Both
p65 transactivation and TNF-alpha
induction of the
p53 promoter depended on an intact NF-kappa B site