◀ Back to EGF

EGF — PLAUR

Text-mined interactions from Literome

Unlü et al., Int J Biol Markers 2003 (Neoplasm Invasiveness...) : EGF stimulation also resulted in increased uPAR transcript in both cell lines
Henic et al., Gynecol Oncol 2006 (Adenocarcinoma...) : This study explored the effects of EGF on uPAR expression in the ovarian cancer cell line OVCAR-3 ... The increase of cell surface uPAR in response to EGF is accompanied by increased release of the soluble form of uPAR ( suPAR ) to the medium as well as by increased cell migration ... Increased cell surface uPAR in response to EGF stimulation results from mobilization of uPAR from detergent-resistant domains, increased expression of uPAR mRNA, and decreased internalization and degradation of uPAR
Baek et al., Oncol Rep 2008 (Carcinoma...) : EGF stimulates uPAR expression and cell invasiveness through ERK, AP-1, and NF-kappaB signaling in human gastric carcinoma cells ... In this study, we investigated the effect of EGF on uPAR expression and the underlying signal pathways in human gastric cancer AGS cells ... EGF induced uPAR mRNA expression in a time- and concentration dependent manner ... EGF also induced uPAR promoter activity ... A specific inhibitor of MEK-1 ( an upstream effector of ERK-1/2 ) and a dominant negative MEK-1 were able to suppress the EGF induced uPAR promoter activity ... Site directed mutagenesis and electrophoretic mobility shift assays demonstrated that the binding sites of transcription factors, activator protein-1 (AP-1) and nuclear factor (NF)-kappaB, are involved in the EGF induced uPAR transcription ... Suppression of the EGF induced uPAR promoter activity by the AP-1 decoy oligonuclotide, as well as expression vectors encoding mutated-type NF-kappaB inducting kinase and I-kappaB, confirmed that the activation of AP-1 and NF-kappaB are essential for the EGF induced uPAR upregulation ... The above results suggest that EGF induces uPAR expression via ERK-1/2, AP-1, and NF-kappaB signaling pathways and, in turn, stimulates cell invasiveness in human gastric cancer AGS cells
Henic et al., Int J Gynecol Cancer 2009 (Adenocarcinoma...) : Estradiol attenuates the stimulatory effect of EGF on cell migration and uPAR expression
Theodorou et al., J Dairy Res 2011 : Furthermore, IGF-1 increased by 2-fold expression of both u-PA and u-PAR while EGF increased by 3·8-fold the expression of only u-PAR
Hu et al., Exp Cell Res 2013 (Breast Neoplasms...) : EGF increased Arf6 activity, ERK phosphorylation, and uPAR expression in a time dependent manner ... GEP100 siRNA or Arf6 siRNA suppressed EGF induced ERK activity and uPAR expression ... Furthermore, blocking ERK signaling with U0126, a specific inhibitor for MEK, markedly inhibited EGF induced uPAR expression and consequently cell invasion
Lund et al., Biochem J 1995 : We have previously found that transforming growth factor-beta, type 1 ( TGF-beta 1 ), increases uPAR gene transcription in the human lung carcinoma cell line A549 and now report that also epidermal growth factor (EGF) and the tumour promoter phorbol 12-myristate 13-acetate ( PMA ) cause increased uPAR transcription and that PMA and TGF-beta 1 in addition increase the stability of uPAR mRNA, while EGF has no effect on this parameter