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IFI27 — SOCS1
Text-mined interactions from Literome
Sugiyama et al., J Biol Chem 2001
:
Overexpression of Grb2 accelerates
Jab1/CSN5 mediated degradation of
p27 , while Grb3-3 expression suppresses it
Tomoda et al., J Biol Chem 2002
:
Nuclear-cytoplasmic translocation plays an important role because leptomycin B ( LMB ), a chemical inhibitor of CRM1 dependent nuclear export, prevents
p27 degradation
mediated by
Jab1/CSN5 ... A Jab1/CSN5 truncation mutant lacking NES reversed
p27 down-regulation
induced by the full-length
Jab1/CSN5 , indicating that this mutant functions as a dominant negative ( DN-Jab1 )
Wan et al., EMBO Rep 2002
:
Jab1 was initially identified as a co-activator of c-Jun, and it also
induces degradation of cell cycle inhibitor
p27 and tumor suppressor p53
Kouvaraki et al., Cancer Res 2006
(Adenocarcinoma...) :
Conversely, down-regulation of
JAB1 by short interfering RNA substantially
increased p27 expression and inhibited progression from G ( 1 ) to S phase of the cell cycle ... Interestingly,
JAB1 mediated
p27 degradation was not impaired when S-phase kinase interacting protein 2 ( Skp2 ), an F-box protein required for the ubiquitination and consequent degradation of p27, was silenced
Berg et al., Hum Pathol 2007
(Carcinoma, Hepatocellular...) :
In transfection studies in the hepatoma cell line Huh 7,
Jab1 overexpression
resulted in reduced
p27 ( Kip1 ) protein levels
Wang et al., J Clin Gastroenterol 2009
(Carcinoma, Squamous Cell...) :
Overexpression of
Jab1 in ECA109 cells
resulted in decreased
p27 level and this decrease was sensitive to 26S proteasome inhibitors
Yang et al., J Cell Physiol 2011
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Jab1 , a co-activator of AP-1 transcription factor and the fifth subunit of the COP9 signalosome,
mediates degradation of the tumor suppressor p53 and
p27 ( Kip1 ) and functions as a tumor promoter in different types of human cancer
Pan et al., Cancer Res 2012
(Nasopharyngeal Neoplasms) :
Jab1/CSN5 negatively
regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma ... Aberrant expression of
Jab1/CSN5 , a negative
regulator of the cell-cycle inhibitor
p27 , is correlated with reduced p27 expression and associated with advanced tumor stage and poor prognosis in several human cancers